ERAB Antibody

Images

 
Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. ( anti-HADHSC )

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Chicken
Conjugate
Unconjugated

Order Details

ERAB Antibody Summary

Immunogen
The immunogen for this antibody was a sequence from 57a.a. to 314a.a. from ERAB(a 314a.a. long protein)
Localization
Mitochondrial
Specificity
ERAB
Clonality
Polyclonal
Host
Chicken
Gene
HSD17B10
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
Positive Control
HADH Lysate (NBL1-11435)

Reactivity Notes

This antibody is reactive against Human, mouse, rat.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
No Preservative
Purity
Immunogen affinity purified

Alternate Names for ERAB Antibody

  • 17-beta-HSD 10
  • 17-beta-hydroxysteroid dehydrogenase 10
  • 17b-HSD10
  • 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
  • ABAD
  • amyloid-beta peptide binding alcohol dehydrogenase
  • CAMR
  • DUPXp11.22
  • EC 1.1.1.178
  • EC 1.1.1.35
  • Endoplasmic reticulum-associated amyloid beta-peptide-binding protein
  • ERAB3-hydroxyacyl-CoA dehydrogenase type-2
  • HADH2AB-binding alcohol dehydrogenase
  • hydroxyacyl-Coenzyme A dehydrogenase, type II, hydroxyacyl-Coenzyme Adehydrogenase, type II
  • hydroxysteroid (17-beta) dehydrogenase 10
  • mental retardation, X-linked, syndromic 10
  • MHBD
  • Mitochondrial ribonuclease P protein 2,3-hydroxyacyl-CoA dehydrogenase type II
  • Mitochondrial RNase P protein 2
  • MRPP2HCD2
  • MRX17
  • MRX31
  • MRXS10
  • SCHAD
  • SDR5C1
  • short chain dehydrogenase/reductase family 5C, member 1
  • short chain L-3-hydroxyacyl-CoA dehydrogenase type 2
  • short chain type dehydrogenase/reductase XH98G2
  • Short-chain type dehydrogenase/reductase XH98G2
  • Type II HADH
  • XH98G2

Background

ERAB is a member of the short-chain dehydrogenase/reductase superfamily. This mitochondrial protein catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. It has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD, a disorder characterized by neurological abnormalities, including psychomotor retardation and loss of mental and motor skills). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. Abundant in human liver, kidney and gonads, but it is present in only negligible amounts in skeletal muscle. At the sub-cellular level, in normal tissues, this protein is located in mithocondria. It is over-expressed in Neurons of patients with Alzheimer's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol HSD17B10
Entrez
Uniprot