Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (268908)

• Reactivity: Hu
• Applications: WB
• Clone: 268908
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (268908) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Endorepellin/Perlecan
  Arg3684-Ser4391 (Ser4003Thr)
  Accession # P98160
• Specificity: Detects human Endorepellin/Perlecan in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: HSPG2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (268908)

• basement membrane-specific heparan sulfate proteoglycan core protein
• endorepellin (domain V region)
• heparan sulfate proteoglycan 2
• Heparan Sulfate Proteoglycan
• HSPG
• perlecan proteoglycan
• perlecan
• PLCSchwartz-Jampel syndrome 1 (chondrodystrophic myotonia)
• PRCAN
• SJA
• SJS
• SJS1

Background

Endorepellin is the C-terminal domain of the heparan sulfate proteoglycan perlecan, which is a modular protein found in basement membranes. Endorepellin is an inhibitor of angiogenesis that blocks endothelial cell adhesion to fibronectin and type I collagen.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Endorepellin/Perlecan/Heparan Sulfate Proteoglycan Antibody (MAB2364)(1)

Publication using MAB2364

• Michael P. Kahle, Boyeon Lee, Tony Pourmohamad, Austin Cunningham, Hua Su, Helen Kim et al. Perlecan domain V is upregulated in human brain arteriovenous malformation and could mediate the vascular endothelial growth factor effect in lesional tissue NeuroReport 2012-07-11 [PMID: 22643235]

Bioinformatics

• Gene Symbol: HSPG2
• Uniprot:
  • P98160()