Human EDNRB/Endothelin R Type B ELISA Kit (Colorimetric)

ELISA: Human EDNRB/Endothelin R Type B ELISA Kit (Colorimetric) [NBP2-80133] - Samples were spiked with high concentrations of Human EDNRB/Endothelin R Type B and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

ELISA: Human EDNRB/Endothelin R Type B ELISA Kit (Colorimetric) [NBP2-80133] - Standard Curve Reference

• Reactivity: Hu
• Applications: ELISA
• Suitable Sample Type: Serum, plasma, and other biological fluids.
• Standard Curve Range: 0.31-20 ng/mL
• Sensitivity: 0.19 ng/mL

Human EDNRB/Endothelin R Type B ELISA Kit (Colorimetric) Summary

• Specificity: This kit recognizes Human ETRB in samples. No Significant cross-reactivity or interference between Human ETRB and analogues was observed.
• Standard Curve Range: 0.31-20 ng/mL
• Sensitivity: 0.19 ng/mL
• Assay Type: Sandwich-ELISA
• Inter-Assay: CV% < 5.14%
• Intra-Assay: CV% < 4.73%
• Spike Recovery: 91-109%
• Sample Volume: 100 ul
• Kit Type: ELISA Kit (Colorimetric)
• Gene: EDNRB

Applications/Dilutions

• Dilutions:
  • ELISA

Packaging, Storage & Formulations

• Storage: Storage of components varies. See protocol for specific instructions.

Alternate Names for Human EDNRB/Endothelin R Type B ELISA Kit (Colorimetric)

• ABCDS
• EDNRB
• endothelin B receptor
• Endothelin receptor non-selective type
• endothelin receptor type B
• ETB
• ET-B
• ETBR
• ET-BR
• ETRB
• HSCR
• HSCR2
• WS4A

Background

The Endothelin Receptor ETB is expressed in most tissues. Mutations of the receptor gene are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. The ETB receptor has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct. The endothelin B receptor has been reported to be expressed in adrenal, aorta, artery, brain, breast, eye, epididymis, ganglion, heart, kidney, liver, lung, ovary, placenta, prostate, skin, testis, uterus, and vessel. ESTs have been isolated from amnion, B-cell/lung/testis, breast, brain, colon, ear, embryo, eye, heart, kidney, liver, liver/spleen, lung, lymph node, placenta, prostate, and skin libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: EDNRB
• Uniprot:
  • P24530()
  • P24530()