EDNRB/Endothelin R Type B Antibody

Images

 
Western Blot: EDNRB/Endothelin R Type B Antibody [NBP2-16335] - Sample (30 ug of whole cell lysate) A: A431 B: H1299 10% SDS PAGE gel, diluted at 1:1000.
Immunohistochemistry-Paraffin: EDNRB/Endothelin R Type B Antibody [NBP2-16335] - Human colon carcinoma. Sample: ETBR antibody [N1N2], N-term dilution: 1:250.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

EDNRB/Endothelin R Type B Antibody Summary

Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human ETBR. The exact sequence is proprietary.
Localization
Cell membrane
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
EDNRB
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
Theoretical MW
50 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.0) and 50% Glycerol
Preservative
0.01% Thimerosal
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for EDNRB/Endothelin R Type B Antibody

  • ABCDS
  • EDNRB
  • endothelin B receptor
  • Endothelin receptor non-selective type
  • endothelin receptor type B
  • ETB
  • ET-B
  • ETBR
  • ET-BR
  • ETRB
  • HSCR
  • HSCR2
  • WS4A

Background

The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Three transcript variants encoding two different isoforms have been found for this gene. While both isoforms bind ET1, they exhibit different responses upon binding, suggesting that they may be functionally distinct. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol EDNRB
Entrez
Uniprot