EDNRA/Endothelin R Type A Antibody

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Immunohistochemistry-Paraffin: EDNRA/Endothelin R Type A Antibody [NLS4069] - Analysis of anti-Endothelin A Receptor antibody with human heart.

Product Details

Summary
Reactivity Hu, Mk, Mu, Rt, Po, Ca, Eq, Ha, Pm, RbSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

EDNRA/Endothelin R Type A Antibody Summary

Immunogen
Synthetic 18 amino acid peptide from 3rd extracellular domain of human Endothelin A Receptor.
Localization
Membrane; multi pass membrane protein.
Specificity
Human Endothelin A Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except EDNRB (72%).
Predicted Species
Mouse (94%), Rat (94%), Porcine (94%), Rabbit (94%), Hamster (94%), Canine (94%), Primate (94%), Equine (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
EDNRA
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 3-16 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Marmoset (100%), Gibbon (94%), Elephant (94%), Panda (94%), Sheep (89%), Bovine (89%), Bat (89%), Opossum (89%), Platypus (89%), Medaka (89%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for EDNRA/Endothelin R Type A Antibody

  • EDNRA
  • endothelin receptor type A
  • endothelin-1 receptor
  • endothelin-1-specific receptor
  • ET1-specific type
  • ETAR
  • ETRA
  • G protein-coupled receptor
  • hET-AR

Background

The ETA receptor is an Endothelin Receptor that mediates the effects of endothelin-1, a mitogen with potent contractile properties. In the human fetal olfactory epithelium cell line FNC-B4, the ETA receptor increases the secretion of gonadotropin-releasing hormone. Increased ETA concentration may be correlated with smooth muscle hypertrophy observed in patients suffering from bladder-outlet obstruction. ETA receptor has been reported in a variety of tissues including placenta, uterus, testis, heart, adrenal gland, lung, kidney, ovary, skin, liver, bladder, large blood vessels, cerebellum, neurons, and meningioma tumor cells. A splice variant has been identified in melanoma (Zhang et al., 1998). ESTs have been isolated from libraries from the above-mentioned tissues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol EDNRA
Entrez