Dynamin Antibody (24GB5985)

• Reactivity: Hu, Mu, Rt
• Applications: WB, ICC/IF, Mycoplasma
• Clone: 24GB5985
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

Dynamin Antibody (24GB5985) Summary

• Immunogen: A synthesized peptide derived from human Dynamin (Uniprot: Q05193)
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: DNM1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Knockdown Validated
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4), 50% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Dynamin Antibody (24GB5985)

• DNM
• DNM1
• dynamin 1
• Dynamin
• dynamin-1
• EC 3.6.5.5

Background

The dynamin family of GTPases is essential for receptor-mediated endocytosis and synaptic vesicle recycling, and it has recently been shown to play a role in vesicle formation from the trans-Golgi network (1). Dynamin-1 is a GTP-, microtubule-, and phospholipid-binding protein that is expressed primarily in brain and almost exclusively expressed in the central nervous system (2). Dynamin-1 is believed to assemble around the necks of clathrin-coated pits and assist in pinching vesicles from the plasma membrane. This role would make dynamin unique among GTPases in its ability to act as a mechanochemical enzyme (1). Dynamin-1 function is apparently essential for scission of newly formed vesicles from the plasma membrane; it has been proposed that dynamin is a regulator of downstream effectors of scission, rather than being directly responsible for it (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DNM1