Dynactin Subunit 1/DCTN1 Antibody (2E4-1C2) - Azide and BSA Free

Western Blot: Dynactin Subunit 1/DCTN1 Antibody (2E4-1C2) [H00001639-M02] - Detection against Immunogen (47.52 KDa) .

• Reactivity: Hu
• Applications: WB, ELISA
• Clone: 2E4-1C2
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

Dynactin Subunit 1/DCTN1 Antibody (2E4-1C2) - Azide and BSA Free Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: DCTN1 (AAH06163, 1 a.a. ~ 198 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS
• Specificity: Reacts with dynactin 1 (p150, glued homolog, Drosophila).
• Isotype: IgG1 Lambda
• Clonality: Monoclonal
• Host: Mouse
• Gene: DCTN1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: This antibody is reactive against recombinant protein in WB and ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Dynactin Subunit 1/DCTN1 Antibody (2E4-1C2) - Azide and BSA Free

• DAP-150
• DCTN1
• DP-150
• dynactin 1 (p150, Glued (Drosophila) homolog)
• Dynactin 1
• Dynactin Subunit 1
• glued homolog, Drosophila)
• HMN7B
• p135
• p150 Glued (Drosophila) homolog
• p150-glued

Background

This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DCTN1
• Entrez:
  • 1639(Human)
• Uniprot:
  • Q14203(Human)