dUTPase Antibody


Western Blot: dUTPase Antibody [NBP2-16241] - Sample (30 ug of whole cell lysate) A: A431 15% SDS PAGE gel, diluted at 1:1000.
Immunohistochemistry-Paraffin: dUTPase Antibody [NBP2-16241] - Immunohistochemical analysis of paraffin-embedded A549 xenograft, using antibody at 1:500 dilution.

Product Details

Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P
0.49 mg/ml

Order Details

dUTPase Antibody Summary

Recombinant protein fragment contain a sequence corresponding to a region within amino acids 2 and 150 of DUT
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at -20C. Avoid freeze-thaw cycles.
0.1M Tris, 0.1M Glycine, 20% Glycerol (pH7).
0.01% Thimerosal
0.49 mg/ml
Immunogen affinity purified


Application Notes
suggested antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0)

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
18 kDa

Reactivity Notes

Human. Expected to cross react based on sequence identity: Mouse (85%), Rat (85%)

Alternate Names for dUTPase Antibody

  • deoxyuridine triphosphatase
  • dUTP pyrophosphatasedUTP nucleotidohydrolase
  • dUTPasedeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
  • EC
  • FLJ20622


This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq]


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


Isotype Controls

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Bioinformatics Tool for dUTPase Antibody (NBP2-16241)

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Contact Information

Product PDFs


Gene Symbol DUT

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