dUTPase Products

Antibodies
dUTPase Antibody
dUTPase Antibody
NBP2-33277
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
dUTPase Antibody (1C9)
dUTPase Antibody (1C9)
H00001854-M01
Species: Hu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Mouse Monoclonal
dUTPase Antibody
dUTPase Antibody
NB100-56624
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Antibody Pairs
dUTPase Antibody Pair
dUTPase Antibody Pair
H00001854-PW1
Species: Hu
Applications: WB, IP
Lysates
dUTPase Overexpression Lysate ...
dUTPase Overexpression Lysate (Nat...
NBL1-10060
Applications: WB
dUTPase Overexpression Lysate ...
dUTPase Overexpression Lysate (Den...
H00001854-T01
Species: Hu
Applications: WB
Proteins
dUTPase Recombinant Protein A ...
dUTPase Recombinant Protein Antigen
NBP2-33277PEP
Species: Hu
Applications: AC
dUTPase Recombinant Protein A ...
dUTPase Recombinant Protein Antigen
NBP2-47479PEP
Species: Hu
Applications: AC
dUTPase Recombinant Protein
dUTPase Recombinant Protein
NBP1-48598
Species: Hu
Applications: PAGE
RNAi
dUTPase RNAi
dUTPase RNAi
H00001854-R06
Species: Hu
Applications: RNAi, RNAi SP
dUTPase RNAi
dUTPase RNAi
H00001854-R05
Species: Hu
Applications: RNAi, RNAi SP
dUTPase RNAi
dUTPase RNAi
H00001854-R04
Species: Hu
Applications: RNAi, RNAi SP

Description

dUTPase encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 1854
Alternate Names
  • EC 3.6.1.23
  • dUTP pyrophosphatasedUTP nucleotidohydrolase
  • dUTPasedeoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
  • FLJ20622
  • deoxyuridine triphosphatase

Research Areas for dUTPase

Find related products by research area and learn more about each of the different research areas below.

Lipid and Metabolism

PTMs for dUTPase

Learn more about PTMs related to dUTPase.

Cleavage
Deamination

Bioinformatics Tool for dUTPase

Discover related pathways, diseases and genes to dUTPase. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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