DTX1 Antibody

Product Discontinued

DTX1 Antibody Summary

• Immunogen: Within the range of amino acids 583-628 of human DTX1 protein were used as the immunogen. 583 599
• Predicted Species: Mouse (100%), Rat (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DTX1
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA 100-1:1000

Reactivity Notes

The amino acid sequence used as immunogen is 100% homologous in human, mouse and rat.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 0.1 ml crude whole Rabbit sera with 50% Glycerol
• Preservative: 0.025% Sodium Azide
• Purity: Unpurified

Alternate Names for DTX1 Antibody

• deltex homolog 1 (Drosophila)
• Deltex1
• DTX1
• Dx-1
• hDTX1
• hDx-1
• protein deltex-1

Background

Protein deltex-1 is a Notch Signaling Pathway protein which belongs to the Deltex Family of proteins. It contains one RING-type zinc finger and two WWE domains. DTX1 acts as regulator of Notch signaling and has functional significance in cell-fate determinations. It mediates the antineural activity of Notch by inhibiting the transcriptional activation mediated by MATCH1. It is involved in neurogenesis, lymphogenesis, myogenesis and MZB (Marginal Zone B) cell differentiation. It promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1. It functions as an ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity. DTX1, along with DTX2 and DTX3, functions as E3 ligases based on their capacity for self ubiquitination.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DTX1
• Uniprot:
  • Q86Y01()