Western blot shows lysate of COLO 205 human colorectal adenocarcinoma cell line. PVDF membrane was probed with 0.5 µg/mL of Mouse Anti-Human Desmoplakin Monoclonal Antibody (Catalog # MAB9080) followed by ...read more
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Reconstitute at 0.5 mg/mL in sterile PBS.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Desmoplakin Antibody (824038) [Unconjugated]
250/210 kDa paraneoplastic pemphigus antigen
desmoplakin (DPI, DPII)
(desmoplakin) is the major high molecular weight protein of desmosomes, the
most common type of intercellular junction in vertebrate epithelial cells. DSP is involved in the organization of the
desmosomal cadherin-plakoglobin complex, as well as in the anchoring of
intermediate filaments to desmosomes.
These functions are thought to impart tensile strength and integrity to
epithelial and vascular tissues.
Mutations in DSP result in several clinical phenotypes, ranging from
mild skin conditions, to severe skin blistering with subsequent dehydration, to
lethal heart defects. Two major
desmoplakin isoforms, DSPI and DSPII, are encoded by alternative mRNA
transcripts differentially spliced from the same gene. Human DSPI is 2,871 amino acids (aa) in length,
while DSPII lacks part of a central alpha-helical rod domain, and is 599 aa
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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