DNMT3A Antibody

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Western Blot: Dnmt3a Antibody [NBP2-03985] - Analysis of Dnmt3a in transfected 293 cell lysate using NBP2-03985 at 1 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and ECL substrate solution were used for this test.

Product Details

Summary
Reactivity Hu, Mu, Bv, Ch, Eq, Fe, PmSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

DNMT3A Antibody Summary

Immunogen
A portion of amino acids 170-220 of human Dnmt3a was used as the immunogen
Specificity
This antibody will not cross react with Dnmt3b.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DNMT3A
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1-3 ug/ml

Reactivity Notes

Reacts with Cat, Chicken, Chimpanzee, Cow, Horse, Human and Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 ml PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for DNMT3A Antibody

  • DNA (cytosine-5-)-methyltransferase 3 alpha
  • DNA (cytosine-5)-methyltransferase 3A
  • DNA cytosine methyltransferase 3A2
  • DNA methyltransferase HsaIIIA
  • DNA MTase HsaIIIA
  • DNMT3A
  • DNMT3A2
  • EC 2.1.1.37
  • M.HsaIIIA

Background

Dnmt3a, also known as DNA (cytosine-5)-methyltransferase 3A, is a nuclear protein belonging to the C5-methyltransferase family with an ADD-type zinc finger and a PWWP domain. This nuclear protein localizes to euchromatin and is essential for genome wide de novo methylation and is also essential for development. DNA methylation is coordinated with methylation of histones. Dnmt3a associates with HDAC1 through its ADD-type zinc-finger. It binds to the ZNF238 transcriptional repressor and is also known to interact with other DNA methyltransferases like Dnmt1 and Dnmt3b

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Discover related pathways, diseases and genes to DNMT3A Antibody (NBP2-03985). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on DNMT3A.

The role of DNMT3A in development
Epigenetics is the study of heritable change in gene activity despite alteration of the hosts DNA sequence.  Change in gene activity done independently of the DNA sequence is achieved by way of histone and DNA methylation.  Gene silencing in DNA ...  Read full blog post.

Go Ahead! Make My DNA
DNA methylation plays a critical role the long-term silencing of transcription and is essential for processes such as embryonic development, germline differentiation, and tissue maturation. Dnmt3a is a member of the C5-methyltransferase family that re...  Read full blog post.

DNMT's: An Overview of 3 DNA Methyltransferases
DNA methyltransferases catalyze the transfer of the methyl group from S-andenosyl methionine (SAM) to DNA. Such methylation has wide ranging function in the cell, including organismal development and cell differentiation. In cancer, abnormal hypermeth...  Read full blog post.

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Bioinformatics

Gene Symbol DNMT3A
Entrez
Uniprot