DNMT3A Products

Antibodies
DNMT3A Antibody
DNMT3A Antibody
NB100-265
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Kits
DNMT3A Assay Kit (Colorimetri ...
DNMT3A Assay Kit (Colorimetric)
KA0683
Applications: Quantification
Lysates
DNMT3A Overexpression Lysate
DNMT3A Overexpression Lysate
NBL1-09970
Species: Hu
Applications: WB
Proteins
Recombinant Human DNMT3A GST ...
Recombinant Human DNMT3A GST (N-Te...
H00001788-Q01
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
Recombinant Human DNMT3A GST ...
Recombinant Human DNMT3A GST (N-Te...
H00001788-P01
Species: Hu
Applications: WB, ELISA, PA, AP
DNMT3A Recombinant Protein An ...
DNMT3A Recombinant Protein Antigen
NBP1-85961PEP
Species: Hu
Applications: AC

Description

Methylation of cytosine residues is essential for mammalian development by regulating gene expression, gene silencing and genomic imprinting (1). This process is controlled by the enzyme DNA (cytosine-5)-methyltransferase 3A (DNMt3a), which is encoded by the DNMT3A gene and has a predicted molecular weight of 102 kDa. DNA methyltransferases including DNMt3a are involved in de novo cytosine methylation and maintenance of embryonic and somatic cells through the transfer of methyl groups to specific CpG structures in DNA (2). Somatic mutations in DNMT3A are responsible for cytogenetically normal acute myeloid leukemia (CN-AML). Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA are linked with cancer (3,4). Mutations in the DNMT3A gene have also been found to cause DNMT3A overgrowth syndrome and myelodysplastic syndromes.

References

1. Thakur, A., Mackin, S. J., Irwin, R. E., O'Neill, K. M., Pollin, G., & Walsh, C. (2016). Widespread recovery of methylation at gametic imprints in hypomethylated mouse stem cells following rescue with DNMT3A2. Epigenetics Chromatin, 9, 53. doi:10.1186/s13072-016-0104-2

2. Ravichandran, M., Lei, R., Tang, Q., Zhao, Y., Lee, J., Ma, L.,... Dawlaty, M. M. (2019). Rinf Regulates Pluripotency Network Genes and Tet Enzymes in Embryonic Stem Cells. Cell Rep, 28(8), 1993-2003.e1995. doi:10.1016/j.celrep.2019.07.080

3. Pang, Y., Liu, J., Li, X., Xiao, G., Wang, H., Yang, G.,... Ren, H. (2018). MYC and DNMT3A-mediated DNA methylation represses microRNA-200b in triple negative breast cancer. J Cell Mol Med, 22(12), 6262-6274. doi:10.1111/jcmm.13916

4. Xia, L., Huang, W., Bellani, M., Seidman, M. M., Wu, K., Fan, D.,... Baylin, S. B. (2017). CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes. Cancer Cell, 31(5), 653-668.e657. doi:10.1016/j.ccell.2017.04.005



Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 1788
Alternate Names
  • DNA Methyltransferase 3 Alpha
  • TBRS
  • DNMT3A2
  • Dnmt3a
  • EC 2.1.1.37
  • DNA cytosine methyltransferase 3A2
  • DNA MTase HsaIIIA
  • DNA (cytosine-5)-methyltransferase 3A
  • DNA methyltransferase HsaIIIA
  • M.HsaIIIA
  • DNA (cytosine-5-)-methyltransferase 3 alpha

Research Areas for DNMT3A

Find related products by research area and learn more about each of the different research areas below.

Chromatin Modifiers
Chromatin Research
DNA Methyltransferases
DNA Repair
DNA replication, Transcription, Translation and Splicing
Epigenetics

Bioinformatics Tool for DNMT3A

Discover related pathways, diseases and genes to DNMT3A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related DNMT3A Blog Posts

Check out the latest blog posts on DNMT3A.
Chromatin reader domains of DNMT-targeting protein, UHRF1, are responsible for cancerous DNA hypermethylation
By Jamshed Arslan, Pharm. D., PhD. DNA methylation represses transcription of many genes, including tumor suppressor genes. A protein called UHRF1 recruits DNA methyltransferases (DNMTs) to establish and maintain DNA...    Read more.
Eat responsibly: Epigenetic downregulation of Ankrd26 gene by long-term high-fat intake promotes obesity and inflammation
By Jamshed Arslan Pharm.D. White adipose tissue (WAT) represents the primary site to store energy in humans. WAT’s endocrine regulation of energy balance is controlled by nutritional status, exercise, and hormones l...    Read more.
The role of DNMT3A in development
Epigenetics is the study of heritable change in gene activity despite alteration of the hosts DNA sequence.  Change in gene activity done independently of the DNA sequence is achieved by way of histone and DNA methylation.  Gene silencing in DNA ...    Read more.
Go Ahead! Make My DNA
DNA methylation plays a critical role the long-term silencing of transcription and is essential for processes such as embryonic development, germline differentiation, and tissue maturation. Dnmt3a is a member of the C5-methyltransferase family that re...    Read more.
DNMT's: An Overview of 3 DNA Methyltransferases
DNA methyltransferases catalyze the transfer of the methyl group from S-andenosyl methionine (SAM) to DNA. Such methylation has wide ranging function in the cell, including organismal development and cell differentiation. In cancer, abnormal hypermeth...    Read more.
Read more DNMT3A related blogs.