139.6 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publications using NBP1-52300 in the following applications:
Use in Mouse reported in scientific literature (PMID:35121402).
Packaging, Storage & Formulations
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
1X PBS (pH 7.0), 20% Glycerol
0.025% Proclin 300
Immunogen affinity purified
Alternate Names for DNA Polymerase gamma Antibody
DNA Polymerase gamma
DNA polymerase subunit gamma-1
Mitochondrial DNA polymerase catalytic subunit
PolG, catalytic subunit
polymerase (DNA directed), gamma
As the only DNA polymerase (pol) present in mitochondria, DNA polymerase gamma (POLG) is necessarily implicated in base excision repair processes to correct oxidative damage to the mitochondrial genome. Therefore, the ability of the catalytic subunit of human POLG has been tested to participate in uracil-provoked base excision repair reconstituted in vitro with purified components. Subsequent to actions of uracil-DNA glycosylase and apurinic/apyrimidinic endonuclease, human POLG is able to fill a single nucleotide gap in the presence of a 5' terminal deoxyribose phosphate (dRP) flap. The catalytic subunit of human pol gamma catalyzes release of the dRP residue from incised apurinic/apyrimidinic sites to produce a substrate for DNA ligase. Faulty replication of the human mitochondrial genome is thought to be the cause of many diseases. The low selectivity of the mitochondrial DNA polymerase is implicated as the cause of many side effects observed in the treatment of viral infections such as HIV.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information go to www.P65Warnings.ca.gov.
Publications for DNA Polymerase gamma Antibody (NBP1-52300)(5)
We have publications tested in 3 confirmed species: Human, Mouse, Rat.
FAQs for DNA Polymerase gamma Antibody (NBP1-52300). (Showing 1 - 1 of 1 FAQs).
I am planning on using your antibody NBP1-52300 and am wondering about the immunogen. I understand that you might not be able to give me the exact sequence, but it is of great importance to me that the antibody does not bind to amino acids 994-1040. Is it possible for you to answer whether the antibody binds to this position or not?
The antibody was raised against recombinant protein fragment containing a sequence corresponding to a region within amino acids 829 and 1201 of DNA polymerase gamma. We typically do not epitope map our antibodies and I cannot determine if this antibody does or does not bind to amino acids 994-1040 however the immunogen sequence does include that fragment.
The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.
Review this Product
Be the first to review our DNA Polymerase gamma Antibody and receive a gift card or discount.