DNA Polymerase gamma Products

Antibodies
DNA Polymerase gamma Antibody ...
DNA Polymerase gamma Antibody
NBP1-33633
Species: Hu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
DNA Polymerase gamma Antibody ...
DNA Polymerase gamma Antibody
NBP1-52300
Species: Hu
Applications: WB, ICC/IF, IHC-P
Host: Rabbit Polyclonal
DNA Polymerase gamma Antibody ...
DNA Polymerase gamma Antibody
NBP2-33800
Species: Hu, Mouse, Rat
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Proteins
DNA Polymerase gamma Partial ...
DNA Polymerase gamma Partial Recom...
H00005428-Q01
Species: Hu
Applications: WB, ELISA, PA
DNA Polymerase gamma Recombin ...
DNA Polymerase gamma Recombinant P...
NBP2-33800PEP
Species: Hu
Applications: AC
RNAi
DNA Polymerase gamma RNAi
DNA Polymerase gamma RNAi
H00005428-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

As the only DNA polymerase (pol) present in mitochondria, DNA polymerase gamma (POLG) is necessarily implicated in base excision repair processes to correct oxidative damage to the mitochondrial genome. Therefore, the ability of the catalytic subunit of human POLG has been tested to participate in uracil-provoked base excision repair reconstituted in vitro with purified components. Subsequent to actions of uracil-DNA glycosylase and apurinic/apyrimidinic endonuclease, human POLG is able to fill a single nucleotide gap in the presence of a 5' terminal deoxyribose phosphate (dRP) flap. The catalytic subunit of human pol gamma catalyzes release of the dRP residue from incised apurinic/apyrimidinic sites to produce a substrate for DNA ligase. Faulty replication of the human mitochondrial genome is thought to be the cause of many diseases. The low selectivity of the mitochondrial DNA polymerase is implicated as the cause of many side effects observed in the treatment of viral infections such as HIV.

Bioinformatics

Entrez Human
Rat
Uniprot Human
Human
Product By Gene ID 5428
Alternate Names
  • PolG, catalytic subunit
  • MIRAS
  • DNA polymerase subunit gamma-1
  • EC 2.7.7.7
  • FLJ27114
  • PolG-alpha
  • SCAE
  • MDP1
  • SANDO
  • Mitochondrial DNA polymerase catalytic subunit
  • POLGAPEO
  • POLG1MTDPS4B
  • MTDPS4A
  • polymerase (DNA directed), gamma

Research Areas for DNA Polymerase gamma

Find related products by research area and learn more about each of the different research areas below.

DNA Polymerases
DNA Repair

PTMs for DNA Polymerase gamma

Learn more about PTMs related to DNA Polymerase gamma.

Phosphorylation
Oxidation
Nitration
Methylation

Bioinformatics Tool for DNA Polymerase gamma

Discover related pathways, diseases and genes to DNA Polymerase gamma. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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