Recombinant Human Dkk-1 Protein

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Func, PAGE, Bioactivity
Concentration
LYOPH

Order Details

Recombinant Human Dkk-1 Protein Summary

Description
A recombinant protein to Dkk-1.

Source: Spodoptera frugiperda, Sf 21 (baculovirus)
Predicted molecular mass of approximately 25.8 kDa, a single polypeptide chain containing 235 amino acids.
Aminio Acid Sequence: Thr32 - His266

Preparation
Method
Lyophilized from 0.2 mm filtered concentrated solution in PBS, pH 7.2.
Details of Functionality
The ED50, as determined by inhibition of Wnt-3a induced alkaline phosphatase production using mouse MC3T3E1 cells, is less than 150 ng/ml.
Source
Baculovirus
Protein/Peptide Type
Recombinant Protein
Gene
DKK1
Endotoxin Note
Less than 1 EU/ug of the rHuDkk-1 as determined by LAL method.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Concentration
LYOPH
Reconstitution Instructions
Centrifuge prior to opening. Reconstitute with sterilized PBS or aqueous buffer to a final concentration of 0.1 mg/ml.

Notes

This lyophilized preparation is stable at 2-8 degrees C, but should be kept at -20 degrees C for long term storage, preferably desiccated. Upon reconstitution, the preparation is most stable at -20 to -80 degrees C, and can be stored for one week at 2-8 degrees C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degrees C to -80 degrees C. Avoid repeated freeze/thaw cycles.

Alternate Names for Recombinant Human Dkk-1 Protein

  • dickkopf (Xenopus laevis) homolog 1
  • dickkopf homolog 1 (Xenopus laevis)
  • dickkopf related protein-1
  • Dickkopf-1
  • dickkopf-related protein 1
  • Dkk1
  • Dkk-1
  • hDkk-1
  • SKdickkopf-1 like

Background

Dickkopf related protein 1 (Dkk-1), along with Dkk -2, -3, -4, and Soggy, are secreted proteins with two conserved cysteine-rich domains. Mature human Dkk-1 is a 40 kDa glycosylated protein that shares 86% aa sequence identity with mouse and rat Dkk-1. Dkk-1 antagonizes Wnt signaling by forming ternary complexes with LRP5/6 and Kremen1 or Kremen2. Its function is important during the development of limbs, neurons, hair follicles, retina, and bone.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol DKK1