Dkk-1 Products

Description

DKK1 is a secreted factor that has been linked to the function of osteoblasts. Elevated DKK1 levels in bone marrow plasma and peripheral blood from patients with multiple myeloma correlated with the gene-expression patterns of DKK1 and were associated with the presence of focal bone lesions. The production of DKK1, an inhibitor of osteoblast differentiation, by myeloma cells is associated with the presence of lytic bone lesions in patients with multiple myeloma.

Bioinformatics

Entrez	22943 Human 13380 Mouse
Uniprot	NM_012242 Human AAH01539 Human AAH01539.1 Human NP_036374 Human NP_036374. Human NP_036374.1 Human O94907 Human O54908 Mouse
Product By Gene ID	22943
Alternate Names	Dkk-1 dickkopf (Xenopus laevis) homolog 1 Dickkopf-1 hDkk-1 dickkopf-related protein 1 DKK-1 SKdickkopf-1 like dickkopf related protein-1 dickkopf homolog 1 (Xenopus laevis)

Diseases related to Dkk-1

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Malignant Neoplasms
Neoplasms
Multiple Myeloma
Osteoporosis
Bone Diseases
Carcinoma
Neoplasm Metastasis
Cell Transformation, Neoplastic
Osteopenia
Fracture
Malignant Neoplasm Of Breast
Arthritis
Mammary Neoplasms
Carcinogenesis
Malignant Paraganglionic Neoplasm
Endometrial Polyp
Inflammation
Bone Neoplasms
Metastatic Malignant Neoplasm To The Bone

Pathways for Dkk-1

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Cell Proliferation
Osteoblast Differentiation
Pathogenesis
Bone Resorption
Cell Growth
Secretion
Regeneration
Methylation
Cell Death
Bone Remodeling
Cell Cycle
Localization
Cell Differentiation
Gastrulation
Angiogenesis
Aging
Bone Development
Cell Migration
Limb Development
Neurogenesis

Research Areas for Dkk-1

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Immunology
Innate Immunity
Signal Transduction
Stem Cell Signaling Pathway
Wnt Signaling Pathway

PTMs for Dkk-1

Learn more about PTMs related to Dkk-1.

Phosphorylation
Methylation
Glycosylation
Demethylation
Cleavage
Dephosphorylation
Phosphorothioation
Deacetylation
Citrullination
Acetylation
Reduction
Deglycosylation

Bioinformatics Tool for Dkk-1

Discover related pathways, diseases and genes to Dkk-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.