Desmin Antibody


Desmin Antibody [NBP1-45143] - Human skeletal muscle cell lysate probed with Goat anti Human Desmin C-Terminal (NBP1-45143)
Desmin Antibody [NBP1-45143] - Analysis of human (A), mouse (B), rat (C) and pig (D) skeletal muscle lysate (35ug protein in RIPA buffer) probed with Goat anti Human desmin antibody (NBP1-45143) at 1.0ugml-1. Primary more

Product Details

Reactivity Hu, Mu, Rt, PoSpecies Glossary
Applications WB, ELISA, IHC, IHC-P
0.5 mg/ml

Order Details

Desmin Antibody Summary

Synthetic peptide sequence C-RDGEVVSEATQQQHE from the C-Terminal region of Desmin (NP_001918.3).
Goat anti Human Desmin recognizes an epitope within the C-terminal (CT) region of human.
Immunogen affinity purified
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  • Western Blot 0.1-0.3 ug/ml
  • ELISA 1:2000
  • Immunohistochemistry 3-6 ug/ml
  • Immunohistochemistry-Paraffin 3-6 ug/ml
Application Notes
This product requires heat-mediated antigen retrieval prior to staining of paraffin sections. Sodium citrate buffer pH6.0 is recommended for this purpose. Goat anti Human Desmin detects a band of approximately 55kDa in human skeletal muscle cell lysates.
Theoretical MW
55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Based on sequence similarity this antibody is expected to react with: Dog, Bovine.

Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
TBS and 0.5% BSA
0.02% Sodium Azide
0.5 mg/ml
Immunogen affinity purified

Alternate Names for Desmin Antibody

  • CMD1I
  • CMD1IFLJ41013
  • CSM1
  • CSM2
  • DES
  • Desmin
  • FLJ12025
  • FLJ39719
  • FLJ41793
  • intermediate filament protein


Desmins belongs to the intermediate filament family, and are class III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z line structures. Defects in Desmin are the cause of desmin related cardio skeletal myopathy (CSM) also known as desmin related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells. A desmin related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I). CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. Antidesmin antibodies are useful in identification of tumours of myogenic origin.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol DES