Desmin Antibody (10H7D2) - BSA Free

Western Blot: Desmin Antibody (10H7D2) [NB110-60508] - Analysis using Desmin mouse mAb against HEK293T cells transfected with the pCMV6-ENTRY control (1) and pCMV6-ENTRY Desmin cDNA (2).

Immunohistochemistry-Paraffin: Desmin Antibody (10H7D2) [NB110-60508] - Analysis of human smooth musde sarcoma, showing cytoplasmic localization using Desmin mouse mAb with DAB staining.

Product Discontinued

Desmin Antibody (10H7D2) - BSA Free Summary

• Immunogen: Purified recombinant fragment of Desmin expressed in E. Coli.
• Specificity: Desmin (10H7D2)
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: DES
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Paraffin 1:200-1:1000
  • Western Blot 1:500-1:2000
• Control:

  Desmin Overexpression Lysate

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.03% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A or G purified

Alternate Names for Desmin Antibody (10H7D2) - BSA Free

• CMD1I
• CMD1IFLJ41013
• CSM1
• CSM2
• DES
• Desmin
• FLJ12025
• FLJ39719
• FLJ41793
• intermediate filament protein

Background

Desmin (DES), with 470-amino acid protein (about 52kDa), belongs to the intermediate filament family and Desmin is class III intermediate filaments found in muscle cells. Homopolymers of Desmin form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane.Mutations in Desmin are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies. Desmin is also expressed in smooth muscle cells of both airways and alveolar ducts and Desmin is a load-bearing protein that stiffens the airways and consequently the lung and modulates airway contractile response.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Desmin Antibody (NB110-60508)(1)

Publication using NB110-60508

• De La Torre P, Pérez-Lorenzo MJ, Alcázar-Garrido Á et al. Perinatal mesenchymal stromal cells of the human decidua restore continence in rats with stress urinary incontinence induced by simulated birth trauma and regulate senescence of fibroblasts from women with stress urinary incontinence Frontiers in cell and developmental biology 2023-01-18 [PMID: 36742196] (Immunocytochemistry/ Immunofluorescence, Human)

Bioinformatics

• Gene Symbol: DES
• Entrez:
  • 1674(Human)