DAP3 Antibody (42C617.1.2)


Western Blot: DAP3 Antibody (42C617.1.2) [NB100-56539] - Analysis of DAP-3 in A) human brain, B) Jurkat and C) NIH 3T3 lysate using this antibody at 5 ug/ml.

Product Details

Reactivity Hu, MuSpecies Glossary
Applications WB
0.5 mg/ml

DAP3 Antibody (42C617.1.2) Summary

The antibody was raised against a synthetic peptide corresponding to amino acids 51-66 of human DAP-3 protein.
In Jurkat, a 45 kDa band is observed.
Protein G purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS containing 0.2% gelatin
0.05% Sodium Azide
0.5 mg/ml
Protein G purified

Reactivity Notes

Reacts with Mouse and Human. 75% sequence identity with rat protein.

Alternate Names for DAP3 Antibody (42C617.1.2)

  • bMRP-10
  • DAP-3Death-associated protein 3
  • death associated protein 3
  • DKFZp686G12159,28S ribosomal protein S29, mitochondrial
  • FLJ12817
  • MGC126058
  • MGC126059
  • mitochondrial 28S ribosomal protein S29
  • MRP-S29Ionizing radiation resistance conferring protein
  • MRPS29S29mt


Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Recently, five novel apoptotic genes (named DAP genes for: Death Associated Proteins) have been identified that code for proteins, which display a diverse spectrum of biochemical activities. These include a novel type of calcium/calmodulin-regulated kinase which carries ankyrin repeats and a death domain (DAP-kinase), a nucleotide-binding protein (DAP-3), a small proline-rich cytoplasmic protein (DAP-1), and a novel homolog of the eIF4G translation initiation factor (DAP-5). DAP-3 has an ATP/GTP binding motive (P-loop) and has been isolated from human and mouse, and named as hDAP-3 and mDAP-3 (Death Associated Protein-3), respectively. Sequence analysis revealed an 82% amino acid identity between human and mouse protein. In situ hybridization and northern blot analysis showed an abundant mRNA expression with a pronounced expression in highly proliferative epithelial compartments. Overexpression of DAP-3 leads to cytochrome c release and induction of cell death. DAP-3 mediated apoptosis was shown to depend on a functional P-loop. mDAP-3 is localized to the mitochondrial matrix and in contrast to cytochrome c, retained its mitochondrial localization during apoptosis induction.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor (R) 405 Labeled NB100-56539AF405
Alexa Fluor (R) 488 Labeled NB100-56539AF488
Alexa Fluor (R) 647 Labeled NB100-56539AF647
Alexa Fluor (R) 700 Labeled NB100-56539AF700
Allophycocyanin Labeled NB100-56539APC
Biotin Labeled NB100-56539B
DyLight 350 Labeled NB100-56539UV
DyLight 405 Labeled NB100-56539V
DyLight 405LS Labeled NB100-56539V3
DyLight 488 Labeled NB100-56539G
DyLight 550 Labeled NB100-56539R
DyLight 650 Labeled NB100-56539C
DyLight 680 Labeled NB100-56539FR
DyLight 755 Labeled NB100-56539IR
HRP Labeled NB100-56539H
PE Labeled NB100-56539PE
PerCP Labeled NB100-56539PCP

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Contact Information

Product PDFs


Gene Symbol DAP3

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