DAP3 Products

Description

Death Associated Protein 3 (DAP3) is a 46 kDa protein carrying a potential nucleotide binding motif (P-loop) at its N-terminal region. The protein is widely expressed, and the expression is upregulated during membrane-receptor mediated apoptosis. In interferon-gamma and Fas induced apoptosis, DAP3 acts as a positive mediator by functioning downstream of the receptor signaling complex and upstream of the effector caspases. However, the mechanism for its function is largely unknown. Interestingly, the N-terminal 230 amino acid fragment of DAP3 alone protects cells from Fas induced cell death. The same region of DAP3 also serves as a binding site for the glucocorticoid receptor and mediates receptor functions.

Bioinformatics

Entrez	65111 Mouse 7818 Human
Uniprot	NM_033657 Human NP_004623 Human NP_004623.1 Human NP_387506.1 Human P51398 Human
Product By Gene ID	7818
Alternate Names	bMRP-10 DAP-3Death-associated protein 3 death associated protein 3 DKFZp686G12159,28S ribosomal protein S29, mitochondrial FLJ12817 MGC126058 MGC126059 mitochondrial 28S ribosomal protein S29 MRP-S29Ionizing radiation resistance conferring protein MRPS29S29mt

Research Areas for DAP3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Core ESC-Like Genes
Stem Cell Markers