Cytokeratin 18 Antibody (SB38b)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-Fr, ICC
Clone
SB38b
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.1 mg/ml

Order Details

Cytokeratin 18 Antibody (SB38b) Summary

Immunogen
Recombinant N-terminal fragment of keratin 18
Marker
Epithelial Marker
Specificity
Keratin 18 (48 kDa)
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
KRT18
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:2000-1:4000
  • ELISA 1:5000-1:20000
  • Immunocytochemistry/Immunofluorescence 10 ug/ml
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 10 ug/ml
  • Immunocytochemistry

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
0.1M BBS (pH 8.2)
Preservative
No Preservative
Concentration
0.1 mg/ml
Purity
Protein A or G purified

Alternate Names for Cytokeratin 18 Antibody (SB38b)

  • Cell proliferation-inducing gene 46 protein
  • cell proliferation-inducing protein 46
  • CK-18
  • CYK18
  • Cytokeratin 18
  • cytokeratin-18
  • K18
  • Keratin 18
  • keratin, type I cytoskeletal 18
  • keratin-18
  • KRT18

Background

Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8). The two keratin types share only 30% sequence homology. (2-6) Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 18, also known as keratin 18, is a type I intermediate filament protein of approximately 48 kDa. It exists as a heterotetramer composed of two type I and two type II keratins. Cytokeratin 18 is expressed in all simple type epithelia and basal cells of many squamous and non-epidermal epithelia, and is often co-expressed with cytokeratin 8. (7-9) Tissues from the gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18. The SB38b monoclonal antibody reacts specifically with keratin 18 and recombinant N-terminal keratin 18.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Cytokeratin 18 Antibody (NBP1-28569). (Showing 1 - 1 of 1 FAQ).

  1. I have a question about NBP1-28569 human sample reactivity. I want to find an antibody which specifically recognize mouse keratin18, I don't want it cross react with human keratin18. It looks like this antibody recognize human keratin 18 as well. Is that right?
    • I have verified that this antibody has actually been tested for Western blot and ICC for both HT29 and HCC38 cell lines (human cell lines). From what I can find in our testing records, we have only tested this for human samples, not mouse. I would recommend choosing one of our other cytokeratin18 antibodies that have been tested for mouse.

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Cytokeratin 18 Antibody (NBP1-28569)

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Blogs on Cytokeratin 18.

Cytokeratin 18 - A Intermediate Filament Cyotskeletal Component
Keratins, also called cytokeratins, are a family of filamentous structural proteins that form the intermediate filaments within epithelial cells. Keratins are differentially expressed depending on both the epithelial cell origin and degree of differen...  Read full blog post.

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Bioinformatics

Gene Symbol KRT18
Entrez