Species: Hu
Applications: WB, Simple Western, IHC, ICC/IF, KO
Host: Sheep Polyclonal
Species: Hu, Mu, Rt, Po, Ca, Ch, Gp, Ha, Rb, Ze
Applications: WB, Flow, ICC/IF, IHC, CyTOF-ready
Host: Mouse Monoclonal
Species: Hu, Ma(-), Bv(-), Ca(-), Ha(-), Mu(-), Po(-), Rt(-), Sh(-)
Applications: WB, Simple Western, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu
Applications: ELISA
Species: Po
Applications: ELISA
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: AC
Description
Cytokeratins (CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie., skin) and non keratinizing cells (ie. mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different cytokeratins (CK) in the molecular range of 40-70 kDa and isoelectric points of 5-8.5 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. Cytokeratin 18 is an acidic keratin which is found primarily in non squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas have been reportedly defined by the use of antibodies that recognize only Cytokeratins 8 and 18.
Bioinformatics
| Entrez |
Human
|
| Product By Gene ID |
3875 |
| Alternate Names |
- Cell proliferation-inducing gene 46 protein
- cell proliferation-inducing protein 46
- CK-18
- CYK18
- Cytokeratin 18
- cytokeratin-18
- K18
- Keratin 18
- keratin, type I cytoskeletal 18
- keratin-18
- KRT18
|
Research Areas for Cytokeratin 18
Find related products by research area and learn more about each of the different research areas below.
CancerCell BiologyCellular Markers
![Western Blot Cytokeratin 18 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Cytokeratin_18_AF7619_Western_Blot_12451.jpg)
![Western Blot Cytokeratin 18 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/af7619_human-cytokeratin-18-affinity-purified-polyclonal-ab-western-blot-1082021135611.jpg)
![Immunocytochemistry Cytokeratin 18 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Cytokeratin_18_AF7619_Immunocytochemistry_15342.jpg)
![Immunohistochemistry Cytokeratin 18 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Cytokeratin_18_AF7619_Immunohistochemistry_13093.jpg)
![Simple Western Cytokeratin 18 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/Cytokeratin_18_AF7619_Simple_Western_20187.jpg)
![Knockout Validated Cytokeratin 18 Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/af7619_human-cytokeratin-18-affinity-purified-polyclonal-ab-knockout-validated-1562021143433.jpg)
![Immunocytochemistry Cytokeratin 18 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af7619_human-cytokeratin-18-affinity-purified-polyclonal-ab-immunocytochemistry-310202312339.jpg)
