Cytokeratin 1 Antibody (LHK1) [DyLight 405]

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Product Details

Summary
Reactivity Hu, RtSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr, IHC-P
Clone
LHK1
Clonality
Monoclonal
Host
Mouse

Cytokeratin 1 Antibody (LHK1) [DyLight 405] Summary

Immunogen
C-terminal peptide sequence of human Cytokeratin 1 [UniProt# P04264]
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Mouse
Gene
KRT1
Purity
Protein G purified
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Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Conjugate
DyLight 405
Format
DyLight 405 (A=400, E=420)
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Applications/Dilutions

Dilutions
  • Western Blot 0.5-2 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:200
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Frozen 5-10 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
Application Notes
This Cytokeratin 1 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry-frozen sections, Immunohistochemistry-paraffin sections and Western blot.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
67 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Cytokeratin 1 Antibody (LHK1) [DyLight 405]

  • CK1
  • CK-1
  • cytokeratin 1
  • Cytokeratin-1
  • cytokeratin-1,67 kDa cytokeratin
  • EHK
  • EHK1
  • epidermolytic hyperkeratosis 1
  • EPPK
  • Hair alpha protein
  • K1
  • keratin 1
  • keratin, type II cytoskeletal 1
  • Keratin-1
  • KRT1A
  • KRTA
  • NEPPK
  • Type-II keratin Kb1

Background

Cytokeratin 1 is a heterotetramer of two type I as well as two type II keratins localized in cell membrane generally associated with keratin-10 (KRT10), and it has been suggested to regulate the activity of kinases such as PKC/SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). Cytokeratin 1 and its heterodimer partner KRT10 are the major constituents of 4 intermediate filament cytoskeleton in suprabasal epidermis/keratinocytes, and their upregulation precedes expression of filaggrin and cornified envelope proteins. Covalent crosslinking of cytokeratin 1 but not of KRT10 to these proteins, in addition to a complex series of lipids, ultimately forms the cornified/lipid envelope, that constitutes the epidermal barrier together with Langerhans cells. Defects in cytokeratin 1 have been linked to epidermolytic hyperkeratosis (EHK), ichthyosis hystrix Curth-Macklin type (IHCM), palmoplantar keratoderma non-epidermolytic (NEPPK), ichthyosis annular epidermolytic (AEI), palmoplantar keratoderma striate type 3 (SPPK3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Cytokeratin 1 Antibody (NB100-2756V) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NB100-2756APC
Biotin Labeled NB100-2756B
DyLight 350 Labeled NB100-2756UV
DyLight 405LS Labeled NB100-2756V3
DyLight 488 Labeled NB100-2756G
DyLight 550 Labeled NB100-2756R
DyLight 650 Labeled NB100-2756C
DyLight 680 Labeled NB100-2756FR
DyLight 755 Labeled NB100-2756IR
FITC Labeled NB100-2756F
HRP Labeled NB100-2756H
PE Labeled NB100-2756PE
PerCP Labeled NB100-2756PCP

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Blogs on Cytokeratin 1

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol KRT1

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