Cytochrome P450 1A2 Antibody (D15) [DyLight 594]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clone: D15
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 594

Cytochrome P450 1A2 Antibody (D15) [DyLight 594] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: MC1a (Preparation C31B4, rat liver cytochrome P4501A2)
• Localization: Liver endoplasmic reticulum, membrane bound.
• Specificity: D15 cross reacts with CYP1A1 & CYP1A2.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CYP1A2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NB600-1490. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Cytochrome P450 1A2 Antibody (D15) [DyLight 594]

• aryl hydrocarbon hydroxylase
• CP12
• CYP1A2
• CYPIA2
• Cytochrome P(3)450
• Cytochrome P450 1A2
• Cytochrome P450 4
• cytochrome P450, family 1, subfamily A, polypeptide 2
• cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
• Cytochrome P450-P3
• dioxin-inducible P3-450
• EC 1.14.14.1
• flavoprotein-linked monooxygenase
• microsomal monooxygenase
• P3-450
• P450 form 4
• P450(PA)
• xenobiotic monooxygenase

Background

In animals, P450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. CYP1A2 is an aryl hydrocarbon hydroxylase involved in the metabolism of endogenous compounds and xenobiotics. It is one of the major drug metabolising enzymes in humans.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CYP1A2