Cytochrome P450 1A2 Antibody (D15) [Alexa Fluor™ Plus 647]

Product Discontinued

Cytochrome P450 1A2 Antibody (D15) [Alexa Fluor™ Plus 647] Summary

• Immunogen: MC1a (Preparation C31B4, rat liver cytochrome P4501A2)
• Localization: Liver endoplasmic reticulum, membrane bound.
• Specificity: D15 cross reacts with CYP1A1 & CYP1A2.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CYP1A2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Cytochrome P450 1A2 Antibody (D15) [Alexa Fluor™ Plus 647]

• aryl hydrocarbon hydroxylase
• CP12
• CYP1A2
• CYPIA2
• Cytochrome P(3)450
• Cytochrome P450 1A2
• Cytochrome P450 4
• cytochrome P450, family 1, subfamily A, polypeptide 2
• cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2
• Cytochrome P450-P3
• dioxin-inducible P3-450
• EC 1.14.14.1
• flavoprotein-linked monooxygenase
• microsomal monooxygenase
• P3-450
• P450 form 4
• P450(PA)
• xenobiotic monooxygenase

Background

In animals, P450 enzymes serve two major functions: (1) biosynthesis of steroids, fatty acids, and bile acids; (2) metabolism of endogenous and a wide variety of exogenous substrates, such as toxins and drugs. The four major families involved in drug metabolism are CYP 1,2,3, and 4. CYP1A2 is an aryl hydrocarbon hydroxylase involved in the metabolism of endogenous compounds and xenobiotics. It is one of the major drug metabolising enzymes in humans.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CYP1A2