Cytochrome P450 1A1 Antibody - Azide and BSA Free

Western Blot: Cytochrome P450 1A1 Antibody [H00001543-D01P] - UroA/UAS03 enhance tight junction proteins in AhR-dependent manner. Cyp1A1 protein levels were measured using immunoblots and quantified band intensities by Image J software. Image collected and cropped by CiteAb from the following publication (//www.nature.com/articles/s41467-018-07859-7) licensed under a CC-BY license.

Western Blot: Cytochrome P450 1A1 Antibody [H00001543-D01P] - Analysis of CYP1A1 expression in transfected 293T cell line by CYP1A1 polyclonal antibody.Lane 1: CYP1A1 transfected lysate(58.20 KDa).Lane 2: Non-transfected lysate.

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: Azide and BSA Free

Cytochrome P450 1A1 Antibody - Azide and BSA Free Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: CYP1A1 (NP_000490.1, 1 a.a. - 512 a.a.) full-length human protein. MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS
• Specificity: Reacts with cytochrome P450, family 1, subfamily A, polypeptide 1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CYP1A1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: This antibody is reactive against transfected lysate in WB and as a detection antibody in ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Cytochrome P450 1A1 Antibody - Azide and BSA Free

• AHH
• AHRR
• aryl hydrocarbon hydroxylase
• CP11
• CYP1
• CYP1A1
• CYPIA1
• cytochrome P1-450, dioxin-inducible
• Cytochrome P450 1A1
• Cytochrome P450 form 6
• cytochrome P450, family 1, subfamily A, polypeptide 1
• Cytochrome P450-C
• Cytochrome P450-P1
• EC 1.14.14.1
• flavoprotein-linked monooxygenase
• P1-450
• P450-C
• P450DX
• subfamily I (aromatic compound-inducible), polypeptide 1
• xenobiotic monooxygenase

Background

This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Cytochrome P450 1A1 Antibody (H00001543-D01P)(2)

Publications using H00001543-D01P

• Pauletto M, Lopparelli R, Pegolo S et al. Significance of the goby Zosterisessor ophiocephalus as a sentinel species for Venice Lagoon contamination: Combining biomarker responses and bioaccumulation. Sci Total Environ. 2019-01-07 [PMID: 30743980]
• R Singh, S Chandrashe, SR Bodduluri, BV Baby, B Hegde, NG Kotla, AA Hiwale, T Saiyed, P Patel, M Vijay-Kuma, MGI Langille, GM Douglas, X Cheng, EC Rouchka, SJ Waigel, GW Dryden, H Alatassi, HG Zhang, B Haribabu, PK Vemula, VR Jala Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway Nat Commun, 2019-01-09;10(1):89. 2019-01-09 [PMID: 30626868]

Bioinformatics

• Gene Symbol: CYP1A1
• Entrez:
  • 1543(Human)
• Uniprot:
  • NP_000490.1(Human)