Cytochrome P450 1A1 Products

Description

The Cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as nicotinamide adenine dinucleotide phosphate (NADPH) and P450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega-hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). As well as fatty acid metabolism, P450s also metabolize many drugs and toxins. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.

Bioinformatics

Entrez	1543 Human 13076 Mouse 24296 Rat 25147 Rat
Uniprot	NP_000490.1 Human AAH23019 Human NM_000499 Human P04798 Human
Product By Gene ID	1543
Alternate Names	xenobiotic monooxygenase CYPIA1 flavoprotein-linked monooxygenase Cytochrome P450-P1 cytochrome P450 1A1 Cytochrome P450-C cytochrome P1-450, dioxin-inducible Cytochrome P450 form 6 aryl hydrocarbon hydroxylase subfamily I (aromatic compound-inducible), polypeptide 1 P450DX AHRR P450-C AHH P1-450 CYP1 CP11 EC 1.14.14.1 cytochrome P450, family 1, subfamily A, polypeptide 1

Diseases related to Cytochrome P450 1A1

Discover more about diseases related to Cytochrome P450 1A1.

Malignant Neoplasms
Neoplasms
Liver Carcinoma
Carcinogenesis
Carcinoma
Malignant Neoplasm Of Breast
Malignant Neoplasm Of Lung
Mammary Neoplasms
Lung Neoplasms
Malignant Squamous Cell Neoplasm
Adenocarcinoma
Liver Neoplasms
Liver Neoplasms, Experimental
Inflammation
Cell Transformation, Neoplastic
Dna Adduction
Malignant Neoplasm Of Prostate
Cholangiocarcinoma

Pathways for Cytochrome P450 1A1

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Cell Cycle
Cell Proliferation
Localization
Pathogenesis
Dna Repair
Conjugation
Excretion
Transport
Cell Growth
Secretion
Methylation
Cell Death
Demethylation
Reverse Transcription
Inflammatory Response
Translation
Dna Methylation
Cell Cycle Arrest
Sulfation
Lactation

Research Areas for Cytochrome P450 1A1

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Breast Cancer
Lipid and Metabolism

PTMs for Cytochrome P450 1A1

Learn more about PTMs related to Cytochrome P450 1A1.

Hydroxylation
Oxidation
Demethylation
Phosphorylation
Methylation
Acetylation
Reduction
Cleavage
Bromination
Ubiquitination
Nitration
Phosphorothioation
Dephosphorylation
Prenylation
Biotinylation
Glycosylation
Formylation
Deamination
Deiodination
Deglycosylation

Bioinformatics Tool for Cytochrome P450 1A1

Discover related pathways, diseases and genes to Cytochrome P450 1A1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.