Cysteinyl Leukotriene R2/CysLTR2 Antibody

Immunohistochemistry-Paraffin: Cysteinyl Leukotriene R2/CysLTR2 Antibody [NLS3305] - IHC staining of human heart.

Immunohistochemistry-Paraffin: Cysteinyl Leukotriene R2/CysLTR2 Antibody [NLS3305] - IHC staining of human spleen.

Product Discontinued

Cysteinyl Leukotriene R2/CysLTR2 Antibody Summary

• Immunogen: Synthetic 15 amino acid peptide from 2nd extracellular domain of human Cysteinyl Leukotriene R2/CysLTR2.
• Localization: Integral membrane protein.
• Specificity: Human CYSLTR2 / CYSLT2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TLR4 (47%).
• Predicted Species: Primate (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CYSLTR2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 4 - 36 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Monkey (87%), Marmoset (87%).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Cysteinyl Leukotriene R2/CysLTR2 Antibody

• CysLT(2)
• CysLT2
• CYSLT2KPG_011
• CYSLT2RHG57
• CysLTR2
• cysteinyl leukotriene CysLT2 receptor
• Cysteinyl Leukotriene R2
• cysteinyl leukotriene receptor 2
• Cysteinyl LeukotrieneR2
• G protein-coupled receptor
• G-protein coupled receptor GPCR21
• G-protein coupled receptor HG57
• HG57
• hGPCR21
• HPN321
• KPG_011

Background

Cysteinyl leukotriene receptor 2 (CysLT2) is a Chemoattractant Receptor that binds neutrophil chemoattractants such as cysteinyl leukotrienes. These ligands have potent proinflammatory activity and are implicated in many features of asthma including edema, bronchial constriction, and hyperreactivity (Bisgaard et al., 2000). Activation of cysteinyl leukotriene receptor 2 induces cell contraction and/or relaxation. CysLT2 expression has been reported in adrenal medulla, blood, brain, heart, kidney, lung, lymph node, ovary, placenta, prostate, pulmonary artery and vein, small intestine, and spleen. ESTs have been isolated from human kidney and liver/spleen libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CYSLTR2
• Entrez:
  • 57105(Human)
• Uniprot:
  • Q9NS75(Human)