Cysteinyl Leukotriene R1/CysLTR1 Antibody - BSA Free

Immunohistochemistry-Paraffin: Cysteinyl Leukotriene R1/CysLTR1 Antibody [NLS1317] - Analysis of anti-CYSLTR1 / CYSLT1 antibody with human lymph node, Hodgkins lymphoma.

Immunohistochemistry-Paraffin: Cysteinyl Leukotriene R1/CysLTR1 Antibody [NLS1317] - Analysis of anti-CYSLTR1 / CYSLT1 antibody with human nasal mucosa, allergic rhinitis, eosinophils.

• Reactivity: Hu, Pm, Pm
• Applications: Flow, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

Cysteinyl Leukotriene R1/CysLTR1 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 20 amino acid peptide from 3rd extracellular domain of human Cysteinyl Leukotriene R1/CysLTR1.
• Epitope: 3rd extracellular domain
• Specificity: Human Cysteinyl Leukotriene R1/CysLTR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except NMU (45%).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CYSLTR1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 6 - 14 ug/ml
• Application Notes: FLOW reactivity reported in (PMID:28115217)..

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Rabbit (85%), Guinea (85%), Bovine (80%), Equine (80%), Porcine (80%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Cysteinyl Leukotriene R1/CysLTR1 Antibody - BSA Free

• CysLT(1)
• CysLT1
• CYSLT1CysLT1
• CYSLT1R
• CYSLTR
• CysLTR1
• Cysteinyl leukotriene D4 receptor
• Cysteinyl Leukotriene R1
• cysteinyl leukotriene receptor 1
• Cysteinyl LeukotrieneR1
• G-protein coupled receptor HG55
• HG55
• HMTMF81
• LTD4 Receptor
• MGC46139

Background

Cysteinyl leukotriene receptor 1, a chemo-attractant Receptor, is detected in spleen, peripheral blood leukocytes, and lung smooth muscle. It binds cysteinyl leukotrienes, which are neutrophil chemo-attractants with potent proinflammatory action. Leukotrienes mediate many features of bronchial asthma such as edema, bronchial constriction, and hyperreactivity. Selective CysLT1 antagonists are used to treat asthma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Cysteinyl Leukotriene R1/CysLTR1 Antibody (NLS1317)(3)

Publications using NLS1317

• Geriolda Topi, Shakti Ranjan Satapathy, Souvik Ghatak, Karin Hellman, Fredrik Ek, Roger Olsson, Roy Ehrnström, Marie-Louise Lydrup, Anita Sjölander High Oestrogen receptor alpha expression correlates with adverse prognosis and promotes metastasis in colorectal cancer Cell Communication and Signaling : CCS 2024-03-28 [PMID: 38549115]
• Salimi M, Stoger L, Liu W, Go S, et al. Cysteinyl leukotriene E4 activates human group 2 innate lymphoid cells and enhances the effect of prostaglandin D2 and epithelial cytokines. J. Allergy Clin. Immunol. 2017-10-01 [PMID: 28115217] (FLOW, Human)
• Woszczek G, Pawliczak R, Qi HY et al. Functional characterization of human cysteinyl leukotriene 1 receptor gene structure. J Immunol 2005-10-15 [PMID: 16210619] (FLOW, Human)

Bioinformatics

• Gene Symbol: CYSLTR1
• Entrez:
  • 10800(Human)
• Uniprot:
  • Q9Y271(Human)