CXCR6 Antibody (221002) [Allophycocyanin]

BaF3 mouse pro-B cell line transfected with mouse CXCR6 and eGFP was stained with either (A) Rat Anti-Mouse CXCR6 APC-conjugated Monoclonal Antibody (Catalog # FAB2145A) or (B) Rat IgG2BAllophycocyanin Isotype Control (Catalog # IC013A). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Mu
• Applications: Flow
• Clone: 221002
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Allophycocyanin

CXCR6 Antibody (221002) [Allophycocyanin] Summary

• Immunogen: CHO Chinese hamster ovary cell line transfected with mouse CXCR6
  Met1-Leu351
  Accession # Q9EQ16
• Specificity: Stains mouse CXCR6-transfected cells but not irrelevant transfectants.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Gene: CXCR6
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CXCR6 Antibody (221002) [Allophycocyanin]

• Bonzo
• BONZOG-protein coupled receptor bonzo
• CD186 antigen
• CD186
• CDw186
• chemokine (C-X-C motif) receptor 6
• C-X-C chemokine receptor type 6
• CXCR6
• CXC-R6
• CXCR-6
• G protein-coupled receptor
• STRL33
• STRL33G-protein coupled receptor STRL33
• TYMSTRCD186

Background

CXCR6, also known as Bonzo and STRL33, is a G protein coupled chemokine receptor expressed on activated T cells and tumor-infiltrating lymphocytes. It binds soluble CXCL16 and membrane-anchored CXCL16 expressed on dendritic cells and macrophages.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for CXCR6 Antibody (FAB2145A)(5)

Publications using FAB2145A

• Wang, Y;Hu, Y;Liu, Y;Shi, C;Yu, L;Lu, N;Zhang, C; Liver-resident CD44hiCD27- ??T Cells Help to Protect against Listeria monocytogenes Infection Cellular and molecular gastroenterology and hepatology 2023-08-21 [PMID: 37611663] (Flow Cytometry, Mouse)
• Alvaro Morales-Molina, Miguel Ángel Rodriguez-Milla, Stefano Gambera, Teresa Cejalvo, Belén de Andrés, María-Luisa Gaspar et al. Toll-like Receptor Signaling–deficient Cells Enhance Antitumor Activity of Cell-based Immunotherapy by Increasing Tumor Homing Cancer Research Communications 3/1/2023 [PMID: 36875156]
• Alvaro Morales-Molina, Miguel Ángel Rodriguez-Milla, Stefano Gambera, Teresa Cejalvo, Belén de Andrés, María-Luisa Gaspar et al. Toll-like Receptor Signaling–deficient Cells Enhance Antitumor Activity of Cell-based Immunotherapy by Increasing Tumor Homing Cancer Research Communications 2023-03-01 [PMID: 36875156] (Flow Cytometry, Mouse)
• Tao Li, Xinlong Lin, Binhai Shen, Wujian Zhang, Yangyang Liu, Hongbin Liu et al. Akkermansia muciniphila suppressing nonalcoholic steatohepatitis associated tumorigenesis through CXCR6+ natural killer T cells Frontiers in Immunology 12/1/2022 [PMID: 36531991]
• Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential PLoS ONE, 2016-04-27;11(4):e0154253. 2016-04-27 [PMID: 27119555] (Flow Cytometry, Mouse)

Bioinformatics

• Gene Symbol: CXCR6
• Uniprot:
  • Q9EQ16()