GPR15 Antibody (367902) [Unconjugated]

Images

 
HEK293 human embryonic kidney cell line transfected with human GRP15 and eGFP was stained with and either (A) Mouse Anti-Human GPR15 Monoclonal Antibody (Catalog # MAB3654) or (B) Mouse IgG2B Flow Cytometry Isotype ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-reported
Clone
367902
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

GPR15 Antibody (367902) [Unconjugated] Summary

Immunogen
NS0 mouse myeloma cell line transfected with human GPR15
Met1-Leu360
Accession # P49685
Specificity
Stains human GPR15-transfected cells but not irrelevant transfectants.
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
GPR15
Purity Statement
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • CyTOF-reported
  • Flow Cytometry 0.25 ug/10^6 cells
Publications
Read Publications using
MAB3654 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GPR15 Antibody (367902) [Unconjugated]

  • Bob
  • Brother of Bonzo
  • G protein-coupled receptor 15
  • GPR15
  • G-protein coupled receptor 15
  • MGC126828
  • MGC126830

Background

GPR15, also known as BOB, is a seven-transmembrane G protein-coupled receptor that is expressed in CD4+ T cells and alveolar macrophages. GPR15 functions as a cellular co-receptor for some isolates of HIV-1, HIV-2, and SIV through interactions with several viral envelope proteins. Human GPR15 shares 96%‑100% amino acid sequence identity with chimpanzee, macaque, and rhesus GPR15, and 76% with mouse GPR15.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for GPR15 Antibody (MAB3654)(9)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: CyTof, Flow Cytometry.


Filter By Application
CyTof
(1)
Flow Cytometry
(8)
All Applications
Filter By Species
Human
(9)
All Species
Showing Publications 1 - 9 of 9.
Publications using MAB3654 Applications Species
M Bauer, B Fink, HJ Seyfarth, H Wirtz, A Frille Tobacco-smoking induced GPR15-expressing T cells in blood do not indicate pulmonary damage BMC Pulm Med, 2017;17(1):159. 2017 [PMID: 29183299] (Flow Cytometry, Human) Flow Cytometry Human
Y Seong, NH Lazarus, L Sutherland, A Habtezion, T Abramson, XS He, HB Greenberg, EC Butcher Trafficking receptor signatures define blood plasmablasts responding to tissue-specific immune challenge JCI Insight, 2017;2(6):e90233. 2017 [PMID: 28352656] (CyTof, Human) CyTof Human
Katherine S Wetzel CXCR6-mediated SIVagmSab Entry into Sabaeus African Green Monkey Lymphocytes Implicates Widespread Use of Non-CCR5 Pathways in Natural Host Infections J. Virol, 2016;0(0):. 2016 [PMID: 27903799] (Flow Cytometry, Human) Flow Cytometry Human
Differential effects of ?4?7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo Gut, 2016;65(10):1642-64. 2016 [PMID: 26209553] (Flow Cytometry, Human) Flow Cytometry Human
Nguyen L, Pan J, Dinh T, Hadeiba H, O'Hara E, Ebtikar A, Hertweck A, Gokmen M, Lord G, Jenner R, Butcher E, Habtezion A Role and species-specific expression of colon T cell homing receptor GPR15 in colitis. Nat Immunol, 2015;16(2):207-13. 2015 [PMID: 25531831] (Flow Cytometry, Human) Flow Cytometry Human
Cartwright A, Schmutz C, Askari A, Kuiper J, Middleton J Orphan receptor GPR15/BOB is up-regulated in rheumatoid arthritis. Cytokine, 2014;67(2):53-9. 2014 [PMID: 24725539] (Flow Cytometry, Human) Flow Cytometry Human
Okamoto , Yukari, Bernstein , Joshua D, Shikano , Sojin Role of C-terminal membrane-proximal basic residues in cell surface trafficking of HIV coreceptor GPR15 protein. J Biol Chem, 2013;288(13):9189-99. 2013 [PMID: 23430259] (Flow Cytometry, Human) Flow Cytometry Human
Kiene M, Marzi A, Urbanczyk A, Bertram S, Fisch T, Nehlmeier I, Gnirss K, Karsten C, Palesch D, Munch J, Chiodi F, Pohlmann S, Steffen I The role of the alternative coreceptor GPR15 in SIV tropism for human cells. Virology, 2012;433(1):73-84. 2012 [PMID: 22874069] (Flow Cytometry, Human) Flow Cytometry Human
Okamoto Y, Shikano S, Phosphorylation-dependent C-terminal Binding of 14-3-3 Proteins Promotes Cell Surface Expression of HIV Co-receptor GPR15. J. Biol. Chem., 2011;286(9):7171-81. 2011 [PMID: 21189250] (Flow Cytometry, Human) Flow Cytometry Human

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Bioinformatics

Gene Symbol GPR15
Uniprot