CXCR6 Products

Description

Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to biological phenotype. The chemokine receptors CCR5 and CXCR4 are the major coreceptors that, together with CD4, govern HIV-1 entry into cells. Some HIV-1, HIV-2, and SIV isolates of different genetic subtypes and biological phenotypes use other chemokine receptors, such as CXCR6, a T-lymphocyte-expressed seven-transmembrane domain receptor that mediates fusion, entry, and trafficking of tumor-infiltrating lymphocytes. CXCR6 has been identified in human blood (T-lymphocytes, activated peripheral blood lymphocytes, monocyte-derived dendritic cells, primitive cord blood cells), placental trophoblasts, T-lymphocytes and dendritic cells in the skin, lymphoid tissues, and in fetal brain astrocytes. ESTs have been isolated from human normal placenta, liver/spleen, and pregnant uterus libraries, and human cancer kidney and uterus libraries.

Bioinformatics

Entrez	100124593 Rat 10663 Human 80901 Mouse
Uniprot	AAB64221 Human AAH33584.1 Human NM_006564 Human NP_006555 Human NP_006555.1 Human O00574 Human Q9EQ16 Mouse U73529 Human
Product By Gene ID	10663
Alternate Names	BONZOG-protein coupled receptor bonzo CD186 antigen CDw186 chemokine (C-X-C motif) receptor 6 C-X-C chemokine receptor type 6 CXC-R6 CXCR-6 G protein-coupled receptor STRL33G-protein coupled receptor STRL33 TYMSTRCD186

Research Areas for CXCR6

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
GPCR
Immunology
Innate Immunity
Virology, Bacteria and Parasites