Mouse CXCL10/IP-10/CRG-2 ELISA Kit (Colorimetric)

Mouse CXCL10/IP-10/CRG-2 ELISA Kit [NBP1-92665] - Data for Mouse IP-10 Platinum ELISA

• Reactivity: Mu
• Applications: ELISA
• Suitable Sample Type: Cell culture supernatant, serum, plasma (EDTA, citrate), buffered solution
• Standard Curve Range: 7.8 - 500 pg/mL
• Sensitivity: 6.5 pg/mL

Mouse CXCL10/IP-10/CRG-2 ELISA Kit (Colorimetric) Summary

• Description: This kit is an enzyme-linked immunosorbent assay for quantitative detection.
• Specificity: The assay detects both natural and recombinant mouse IP-10. The interference of circulating factors of the immune systeme was evaluated by spiking these proteins at physiologically relevant concentrations. There was no crossreactivity detected.
• Standard Curve Range: 7.8 - 500 pg/mL
• Sensitivity: 6.5 pg/mL
• Assay Type: Sandwich ELISA
• Inter-Assay: CV% < 7.20%
• Intra-Assay: CV% < 8.40%
• Spike Recovery: The unspiked cell culture supernatant was used as blank in these experiments. The recovery ranged from 55% to 118% with an overall mean recovery of 90%.
• Sample Volume: 50 uL
• Kit Type: ELISA Kit (Colorimetric)
• Gene: CXCL10

Applications/Dilutions

• Dilutions:
  • ELISA

Packaging, Storage & Formulations

• Storage: Storage of components varies. See protocol for specific instructions.

Alternate Names for Mouse CXCL10/IP-10/CRG-2 ELISA Kit (Colorimetric)

• C7
• chemokine (C-X-C motif) ligand 10
• CRG2
• CRG-2
• CXCL10
• gIP-10
• IFI10
• INP10
• IP-10
• mob-1
• SCYB10

Background

IP-10 is a member of the CXC subfamily of chemokines expressed by monocytes. It plays a pivotal role in immune system development and deployment. The Interferon-gamma inducible protein -10kD (IP-10) displays pleiotropic functions including stimulation of monocytes, natural killer and T-cell migration, regulation of T-cell and bone marrow progenitor maturation, modulation of adhesion molecule expression as well as inhibition of angiogenesis. Through this inhibitory effect on neovascularization IP-10 exhibits anti-tumoral effects. It shares a common receptor, CXCR3, with the chemokine MIG, but has been shown to play a distinct role in host defense in infections. IP-10 is further involved in allergic contact dermatitis reactions and other allergic diseases. It appears during immune-mediated processes, in inflammation of the nervous system and in Alzheimer's disease. Its involvement in the regulation of fibroproliferation following inflammatory lung injury has been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

Publications for CXCL10/IP-10/CRG-2 ELISA Kit (NBP1-92665)(3)

Publications using NBP1-92665

• Lee H, Noh J, Song J et al. Metformin reduces the risk of developing influenza A virus related cardiovascular disease Heliyon 2023-09-01 [PMID: 37810823] (ELISA)
• Noman M, Parpal S, Van Moer K et al. Inhibition of Vps34 reprograms cold into hot inflamed tumors and improves antiPD-1/PD-L1 immunotherapy Sci. Adv. 2020-05-01 [PMID: 32494661] (ELISA, Mouse)
• Oikawa D, Sato Y, Ohtake F et al. Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses Communications biology 2020-04-23 [PMID: 32246052] (ELISA)

Bioinformatics

• Gene Symbol: CXCL10