CRTH-2/GPR44 Antibody

Images

 
Immunohistochemistry-Paraffin: CRTH-2/GPR44 Antibody [NBP1-02355] - Staining of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration ...read more

Product Details

Summary
Reactivity Hu, PmSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Order Details

CRTH-2/GPR44 Antibody Summary

Immunogen
Synthetic 20 amino acid peptide from C-terminal cytoplasmic domain of human GPR44 / CRTH2.
Specificity
Human GPR44 / CRTH2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except KCNN2 (50%).
Predicted Species
Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PTGDR2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Paraffin 15 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Porcine (85%), Elephant (80%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for CRTH-2/GPR44 Antibody

  • CD294 antigen
  • CD294
  • Chemoattractant receptor-homologous molecule expressed on Th2 cells
  • CRTH2
  • CRTH-2
  • CRTH2chemoattractant receptor homologous molecule expressed on T helper type 2 cells
  • DL1R
  • DP2
  • G protein-coupled receptor 44
  • GPR44
  • PGD2R
  • PTGDR2
  • putative G-protein coupled receptor 44

Background

GPR44, also called CRTH2, is a Prostanoid Receptor that binds prostaglandin D2. PGD2 signals through CRTH2 to induce Th2, eosinophil, and basophil chemotaxis in a G-alpha(i) dependent manner. CRTH2 may play a role in mast cell-mediated immune responses such as those involved in allergic reactions. This receptor is upregulated in activated T helper-2 (Th2) cells, peripheral blood basophils, and eosinophils, but not in Th1 lineage cells. It may be a useful marker for Th2 and Tc2 cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PTGDR2
Entrez
Uniprot