CREBL2 Recombinant Protein Antigen

Product Discontinued

CREBL2 Recombinant Protein Antigen Summary

• Description: A recombinant protein antigen with a N-terminal His6-ABP tag corresponding to human CREBL2.
  
  

  Source: E. coli

  Amino Acid Sequence: REELEMYKQWCMAMDQGKIPSEIKALLTGEEQNKSQQNSSRHTKAGKTDANSNSW

  Fusion Tag: N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G)

  This product is intended to be used as a blocking antigen for antibody competition assays. Any other use of this antigen is done at the risk of the user. The use of this product for commercial production is strictly prohibited. Please contact technical support if you have any questions.

• Source: E. coli
• Protein/Peptide Type: Recombinant Protein Antigen
• Gene: CREBL2
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Applications/Dilutions

• Dilutions:
  • Antibody Competition 10 - 100 molar excess
• Application Notes: This recombinant antigen is only intended to be used as a blocking agent to confirm antibody specificity with the corresponding antibody, catalog number NBP1-86200.

  It is purified by IMAC chromatography, and the expected concentration is greater than 0.5 mg/ml.

  For current lot information, including availability, please contact our technical support team click nb-technical@bio-techne.com

• Theoretical MW: 24 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS and 1M Urea, pH 7.4.
• Preservative: No Preservative
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Alternate Names for CREBL2 Recombinant Protein Antigen

• cAMP responsive element binding protein-like 2
• cAMP-responsive element-binding protein-like 2
• MGC117311
• MGC138362

Background

cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonlydeleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoieticmalignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity withCRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consistsof about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved inprotein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance ofCREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: CREBL2