CREBL2 Products

Description

cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonlydeleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoieticmalignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity withCRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consistsof about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved inprotein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance ofCREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. (provided by RefSeq)

Bioinformatics

Entrez	1389 Human
Uniprot	NP_001301 Human NP_001301.1 Human
Product By Gene ID	1389
Alternate Names	cAMP responsive element binding protein-like 2 cAMP-responsive element-binding protein-like 2 MGC117311 MGC138362

Research Areas for CREBL2

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Stem Cell Markers