CRBN Antibody (978015) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: IHC, ICC/IF
• Clone: 978015
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

CRBN Antibody (978015) [Alexa Fluor® 647] Summary

• Immunogen: Synthetic peptide Human CRBN
  Accession # Q96SW2
• Specificity: Detects human CRBN in immunocytochemistry and immunohistochemistry.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CRBN Antibody (978015) [Alexa Fluor® 647]

• Cereblon
• CRBN
• DKFZp781K0715
• MGC27358
• MRT2
• MRT2A
• non-syndromic, autosomal recessive, 2A
• protein cereblon
• Protein X 0001

Background

Cerbeblon  (CRBN) is a substrate recognition component of an E3 protein ligase complex which mediates ubiquitination and proteasomal degradation of target proteins. In embryonic development, degradation of regulatory proteins is required for normal limb outgrowth. Thalidomide, a teratogenic drug prescribed to pregnant women in the 1950s, binds to CRBN in the E3 protein ligase complex. Despite its teratogenic effect, CRBN is used to treat multiple myeloma and complications of leprosy. Widely expressed, CRBN may play a role in memory and learning by regulating assembly and surface expression of large-conductance calcium-activated potassium channels in hippocampal neurons. Mutations in the CRBN gene is linked to the Mental Retardation, Autosomal Recessive2a (MR2A) form of mental retardation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.