COMT Antibody Blocking Peptide

• Reactivity: Hu
• Applications: AC
• Concentration: LYOPH

COMT Antibody Blocking Peptide Summary

• Description: A human COMT antibody blocking peptide.

  Source: Synthetic

  Amino Acid Sequence: GDTKEQRILNHVLQC

• Source: Synthetic
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: COMT
• Purity: >50%, by HPLC

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NB100-1780. For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from a 5pmol/ul solution in 5% (v/v) acetonitrile/H2O and TFA salt.
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: >50%, by HPLC
• Reconstitution Instructions: Reconstitute in 200ul distilled water to obtain a 0.5mg/ml peptide solution.

Alternate Names for COMT Antibody Blocking Peptide

• catechol O-methyltransferase
• catechol-O-methyltransferase
• COMT
• EC 2.1.1.6

Background

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. The transcript variants are formed through the use of alternative translation initiation sites and promoters.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: COMT