Complement Factor H-related 4/CFHR4 Antibody

Images

 
There are currently no images for Complement Factor H-related 4/CFHR4 Antibody (NBP2-77378).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IA
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.1 mg/ml

Order Details

Complement Factor H-related 4/CFHR4 Antibody Summary

Immunogen
Recombinant FHR4 fragment SCR2-4.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
CFHR4
Purity
IgG purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • Immunoassay
Application Notes
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. WB: A non-reduced and/or reduced sample treatment and SDS-Page was used. The band size is 86 kDa. IA: It can be used as detection antibody.

Packaging, Storage & Formulations

Storage
Store at 4°C.
Buffer
0.2 um filtered solution in PBS and 0.1% BSA
Preservative
0.02% Sodium Azide
Concentration
0.1 mg/ml
Purity
IgG purified

Alternate Names for Complement Factor H-related 4/CFHR4 Antibody

  • complement factor H-related protein 4
  • CFHL4
  • CFHR4
  • Complement Factor Hrelated 4
  • Complement Factor H-related 4
  • FHR4
  • FHR-4

Background

Polyclonal antibody NBP2-77378 recognizes human complement factor H related protein 4 (FHR4). The complement system is the first line of defense against pathogens and facilitates elimination of apoptotic and damaged cells. Complement factor H (fH) is an abundant plasma protein that negatively regulates the alternative pathway and the C3b amplification loop. The proteins encoded by the fH gene family includes besides fH also five fH-related proteins (FHR1-5), encoded by closely linked but unique genes. Like fH these proteins consist of repeating short consensus repeats (SCRs). fH competes with fB for binding to C3b and C3b(H2O) thereby blocking the formation of the convertase, accelerates decay of C3-convertases and is a cofactor for fI. The function of FHR proteins is less clear. FHRs are produced primarily in the liver and secreted in the plasma. FHR4 binds to the C3d region of C3b. In contrast to fH, the FHR4-C3b interaction promotes complement activation. Two transcripts of the FHR4 gene exist: FHR4B and FHR4B, consisting of respectively 9 and 5 SCRs (86 & 42kDa). Both variants have different binding profiles to C3b. Suggested ligand in complement activation of FHR4 is pentameric CRP.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

AF4779
Species: Hu
Applications: WB, IHC
NB200-540
Species: Mu
Applications: Flow, IA, ICC/IF, IHC, IHC-Fr, IHC-P, IP, CyTOF-ready, Flow-IC
MAB4247
Species: Hu
Applications: WB, IP
NBP2-92615
Species: Hu, Mu
Applications: WB, ICC/IF
NBP2-52441
Species: Hu, Mu
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P, CyTOF-ready
NBP1-78159
Species: Hu, Rt, Po, Bv
Applications: WB, EM, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, In vitro, PLA, RIA
NBP1-31336
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
MAB5484
Species: Hu
Applications: WB, IP
NBP1-89985
Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P
MAB5938
Species: Hu
Applications: WB, ICC
NBP1-07010
Species: Hu, Rt, Pm
Applications: WB, ELISA, ICC/IF
NBP2-70997
Species: Hu
Applications: WB, IHC
AF5739
Species: Hu, Mu, Rt
Applications: WB
NBP1-89811
Species: Hu
Applications: WB, IHC, IHC-P
MAB2005
Species: Hu
Applications: WB, Flow, CyTOF-ready
NBP2-77378
Species: Hu
Applications: WB, IA

Publications for Complement Factor H-related 4/CFHR4 Antibody (NBP2-77378) (0)

There are no publications for Complement Factor H-related 4/CFHR4 Antibody (NBP2-77378).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Complement Factor H-related 4/CFHR4 Antibody (NBP2-77378) (0)

There are no reviews for Complement Factor H-related 4/CFHR4 Antibody (NBP2-77378). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Complement Factor H-related 4/CFHR4 Antibody (NBP2-77378) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Additional Complement Factor H-related 4/CFHR4 Products

Bioinformatics Tool for Complement Factor H-related 4/CFHR4 Antibody (NBP2-77378)

Discover related pathways, diseases and genes to Complement Factor H-related 4/CFHR4 Antibody (NBP2-77378). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Complement Factor H-related 4/CFHR4 Antibody (NBP2-77378)

Discover more about diseases related to Complement Factor H-related 4/CFHR4 Antibody (NBP2-77378).
 

Pathways for Complement Factor H-related 4/CFHR4 Antibody (NBP2-77378)

View related products by pathway.

Blogs on Complement Factor H-related 4/CFHR4

There are no specific blogs for Complement Factor H-related 4/CFHR4, but you can read our latest blog posts.
Coronavirus Brochure

Customers Who Bought This Also Bought

Contact Information

Learn the difference between western blot and simple western

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Complement Factor H-related 4/CFHR4 Antibody and receive a gift card or discount.

Bioinformatics

Gene Symbol CFHR4