Complement Factor I Antibody - BSA Free

Staining of human liver shows moderate cytoplasmic positivity in hepatocytes.

Staining of human epididymis shows strong positivity in plasma in blood vessels.

Staining of human kidney shows moderate cytoplasmic positivity in cells in tubules.

Staining of human skin shows very weak cytoplasmic positivity in squamous epithelial cells.

• Reactivity: Hu
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Complement Factor I Antibody - BSA Free Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: ETSLAECTFTKRRTMGYQDFADVVCYTQKADSPMDDFFQCVNGKYISQMKACDGINDCGDQSDELCCKACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGCAGFASVAQEETEILTADMDAERRRIKSLLPKLSC
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CFI
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Paraffin 1:200 - 1:500
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  Complement Factor I Protein (NBP1-88267PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for Complement Factor I Antibody - BSA Free

• AHUS3
• C3b Inactivator
• C3B/C4B inactivator
• C3BINA
• C3b-inactivator
• CFI
• complement component I
• complement control protein factor I
• complement factor I heavy chain
• Complement Factor I
• EC 3.4.21
• EC 3.4.21.45
• FIC3b-INA
• I factor (complement)
• IF
• KAF
• Konglutinogen-activating factor
• light chain of factor I

Background

Factor I is a plasma protein of molecular weight 88 kDa, consisting of two disulphide linked chains of 50 and 38 kDa. Factor I is a serine protease with a high degree of specificity for C3b and C4b. It has a requirement for protein cofactors for cleavage of these complement proteins, Factor H, CR1 or MCP are required for C3b cleavage and C4bp or CR1 for C4b cleavage.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CFI