Complement Factor H-related 2/CFHR2/CFHL2 Antibody (510511)

• Reactivity: Hu
• Applications: WB, IP
• Clone: 510511
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

Complement Factor H-related 2/CFHR2/CFHL2 Antibody (510511) Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Complement Factor H-related 2/CFHR2
  Glu19-Glu268
  Accession # P36980
• Specificity: Detects human Complement Factor H-related 2/CFHR2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human (rh) CFHR1 or rhCFHR5 is observed.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: CFHR2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 25 ug/mL
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Complement Factor H-related 2/CFHR2/CFHL2 Antibody (510511)

• CFHL2
• CFHL2FHR-2
• CFHR2
• Complement Factor Hrelated 2
• Complement Factor H-related 2
• factor H-related gene 2
• FHR2
• FHR2DDESK59
• H factor (complement)-like 3
• H factor-like 3
• H factor-like protein 2
• HFL3
• HFL3complement factor H-related protein 2

Background

Complement Factor H-related 2 (CFHR2) is synthesized in the liver and secreted into plasma. It may be involved in complement regulation. It can also be associated with lipoproteins and may play a role in lipid metabolism. Human CFHR2 shares 48% identity with that of rat.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Complement Factor H-related 2/CFHR2/CFHL2 Antibody (MAB5484)(4)

Publications using MAB5484

• Anna E. van Beek, Richard B. Pouw, Victoria J. Wright, Neneh Sallah, David Inwald, Clive Hoggart et al. Low Levels of Factor H Family Proteins During Meningococcal Disease Indicate Systemic Processes Rather Than Specific Depletion by Neisseria meningitidis Frontiers in Immunology 2022-05-26 [PMID: 35720329]
• Laura Lorés-Motta, Anna E. van Beek, Esther Willems, Judith Zandstra, Gerard van Mierlo, Alfred Einhaus et al. Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration The American Journal of Human Genetics 2021-08-01 [PMID: 34260947]
• Laura Lorés-Motta, Anna E. van Beek, Esther Willems, Judith Zandstra, Gerard van Mierlo, Alfred Einhaus et al. Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration The American Journal of Human Genetics 2021-08-01 [PMID: 34260947] (ELISA Detection, Human)
• Anna E. van Beek, Richard B. Pouw, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Pleuni Ooijevaar-de Heer et al. Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma Frontiers in Immunology 2017-10-18 [PMID: 29093712]

Bioinformatics

• Gene Symbol: CFHR2
• Uniprot:
  • P36980()