Complement Factor MASP3/MASP1 Antibody

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IP
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

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Complement Factor MASP3/MASP1 Antibody Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human Complement Factor MASP3
Ile450-Val721
Accession # NP_624302
Specificity
Detects human Complement Factor MASP3 Catalytic Domain in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
MASP1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 ug/mL
  • Immunoprecipitation 25 ug/mL
Publications
Read Publication using
AF1724 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Complement Factor MASP3/MASP1 Antibody

  • Complement Factor MASP3
  • Complement factor MASP-3
  • Complement-activating component of Ra-reactive factor
  • CRARF1
  • CRARFMAP1
  • DKFZp686I01199
  • EC 3.4.21
  • EC 3.4.21.-
  • EC 3.4.21.104
  • EC 3.4.21.42
  • FLJ26383
  • mannan-binding lectin serine peptidase 1 (C4/C2 activating component ofRa-reactive factor)
  • mannan-binding lectin serine protease 1 (C4/C2 activating component ofRa-reactive factor)
  • mannan-binding lectin serine protease 1
  • Mannose-binding lectin-associated serine protease 1
  • Mannose-binding protein-associated serine protease
  • MAp44
  • MASP
  • MASP1
  • MASP-1
  • MASP3
  • MGC126283
  • MGC126284
  • PRSS5
  • Ra-reactive factor serine protease p100
  • RaRF
  • Serine protease 5

Background

MASP3 is a member of the MASPs involved in mannan-binding lectin (MBL) complement pathway (1). The MBL pathway is initiated by the binding of MBL to specific carbohydrate structures found on the surface of a variety of microorganisms. Activation of the complement pathway via MBL is initiated by specific MASPs. Three MASPs have been identified and all have domain structures similar to those of C1r and C1s with a heavy chain (chain A) and a light chain (chain B). Chain A is composed of CUB1, EGF, CUB2, CCP1 and CCP2 while chain B corresponds to the catalytic domain found in many serine proteases. MASP1 and MASP3 are two alternatively spliced products of a single gene, which contain the same A chains but entirely different B chains. Distinct MASPs found in different MBL oligomers may have different biological activities. For example, MASP3, found together with MASP2, downregulates the C4 and C2 cleaving activity of MASP2. The protease activity of MASP3 is first revealed here using rhMASP3CD (2), which is inhibited by serine protease inhibitors such as Ecotin and AEBSF (Catalog # 1328-PI and EI001).

  1. Dahl, M.R. et al. (2001) Immunity 15:127.
  2. Cortesio, C.L. and W. Jiang (2006) Arch. Biochem. Biophys. 449:164.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Complement Factor MASP3/MASP1 Antibody (AF1724)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Western Blot.


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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin BAF1724

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Bioinformatics

Gene Symbol MASP1
Uniprot