Complement Component C1qA Antibody (JL-1)


There are currently no images for Complement Component C1qA Antibody (NBP1-51139).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity Hu, RtSpecies Glossary
Applications WB, Func, IA, ICC/IF, IHC, IHC-Fr
0.1 mg/ml

Order Details

View Available Conjugates
Catalog# & Conjugate Size Price

Complement Component C1qA Antibody (JL-1) Summary

Purified mouse C1QA
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Western Blot 1:100-1:2000
  • Functional
  • Immunoassay
  • Immunocytochemistry/Immunofluorescence 1:10-1:500
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500

Reactivity Notes

Human and Rat

Packaging, Storage & Formulations

Store at 4C. Do not freeze.
0.2 um filtered solution in PBS and 0.1% BSA
No Preservative
0.1 mg/ml
Protein A or G purified


Positive Control: Spleen and kidney tissue of wild-type mice (Ref.1) Negative control: Spleen and kidney tissue of C1q -/- mice (Ref.1)

Alternate Names for Complement Component C1qA Antibody (JL-1)

  • C1QA complement component 1, q subcomponent, A chain
  • C1QA
  • Complement Component C1qA


The monoclonal antibody JL-1 recognizes the collagen-like region (CLR) of mouse C1q, a 459 kDa molecule consisting of three individual polypeptide chains. The antibody has been generated by immunization of C1q-/- C57BL/6 mice with purified mouse C1q. C1q forms together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore, C1q can also recognize molecular patterns associated with pathogens and it can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto antigens, thereby preventing stimulation of the immune system. C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defence and clearance of immune complexes. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE). The monoclonal antibody JL-1 is reactive with the collagen-like region (CLR) only, which is the same region to which autoantibodies in mice and humans are binding. Anti-C1q autoantibodies deposit in glomeruli together with C1q but induce overt renal disease only in the context of glomerular immune complex disease. This provides an explanation why anti-C1q antibodies are especially pathogenic in patients with SLE.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Species: Hu, Mu
Applications: WB
Species: Mu
Applications: WB, Flow, IA, ICC/IF, IHC, IHC-Fr, IHC-P, IP, CyTOF-ready, Flow-IC
Species: Hu
Applications: WB, Flow, ICC/IF, IHC-P
Species: Hu
Applications: Flow, CyTOF-ready, ICC, Neut
Species: Mu
Applications: WB, Flow, CyTOF-ready
Species: Hu
Applications: WB, IP, PLA
Species: Hu, Mu, Rt, Mk
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Species: Hu
Applications: WB, IP
Species: Hu
Applications: ICC/IF, IHC-Fr, IHC-P
Species: Hu, Mu
Applications: WB, Simple Western
Species: Hu, Mu, Rt
Applications: WB, Flow, IHC, IHC-P, CyTOF-ready, Flow-CS
Species: Hu, Rt
Applications: WB, Func, IA, ICC/IF, IHC, IHC-Fr

Publications for Complement Component C1qA Antibody (NBP1-51139) (0)

There are no publications for Complement Component C1qA Antibody (NBP1-51139).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Complement Component C1qA Antibody (NBP1-51139) (0)

There are no reviews for Complement Component C1qA Antibody (NBP1-51139). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for Complement Component C1qA Antibody (NBP1-51139) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies


Isotype Controls

Other Available Formats

Biotin Labeled NBP1-51140B

Additional Complement Component C1qA Products

Complement Component C1qA NBP1-51139

Bioinformatics Tool for Complement Component C1qA Antibody (NBP1-51139)

Discover related pathways, diseases and genes to Complement Component C1qA Antibody (NBP1-51139). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Complement Component C1qA Antibody (NBP1-51139)

Discover more about diseases related to Complement Component C1qA Antibody (NBP1-51139).

Pathways for Complement Component C1qA Antibody (NBP1-51139)

View related products by pathway.

PTMs for Complement Component C1qA Antibody (NBP1-51139)

Learn more about PTMs related to Complement Component C1qA Antibody (NBP1-51139).

Research Areas for Complement Component C1qA Antibody (NBP1-51139)

Find related products by research area.

Blogs on Complement Component C1qA

There are no specific blogs for Complement Component C1qA, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our Complement Component C1qA Antibody (JL-1) and receive a gift card or discount.


Gene Symbol C1QA