Complement C5 Antibody (568)

• Reactivity: Hu
• Applications: WB, ELISA
• Clone: 568
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: 0.1 mg/ml

Complement C5 Antibody (568) Summary

• Immunogen: Unfortunately, this information is considered to be commercially sensitive.
• Specificity: This reacts with an epitope on C5 and on C5b.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: C5
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunoassay
  • Western Blot 1:100-1:2000
• Application Notes: WB: 188.3 kDa. Optimal dilutions/concentrations should be determined by the end user.

Packaging, Storage & Formulations

• Storage: Store at 4C.
• Buffer: PBS containing 0.1% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.1 mg/ml
• Purity: Protein G purified

Alternate Names for Complement C5 Antibody (568)

• anaphylatoxin C5a analog
• C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
• C5
• complement C5
• complement component 5
• CPAMD4MGC142298
• FLJ17816
• FLJ17822

Background

C5 is synthesised in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190kDa glycoprotein consisting of a disulphide linked alpha-chain (115kDa) and beta-chain (75kDa). C5 occurs in plasma at about 75mg/L. It is activated via either the classical or the alternative complement pathway, by protoelytic cleavage of C5a (11.5kDa) from the N-terminal of the alpha-chain. C5a is a potent anaphylotoxin and stimulates directed migration of neutrophils, eosinophils, basophils and monocytes. The other fragment, C5b,initiates the assembly of the membrane attack complex that mediates the cytolysis of viral and bacterial pathogens.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for Complement C5 Antibody (NB120-11879). (Showing 1 - 1 of 1 FAQ).

1. I am interested in purchasing the following antibody: catalog # NB120-11879 Complement C5 Ab. In which epitope its been raised against? What volume do you get out of 0.05mg? Also, what is its cost and does it work on ELISA?
   • NB120-11879 is not epitope mapped but it is known that it reacts with an epitope on C5 and on C5b. The concentration is 0.1 mg/mL which is a volume of 500 uL and it has not yet been validated for use in ELISA. Regarding the price of this product, please use our website to select your country, which will allow you to view the country specific pricing, availability and technical support information.

Bioinformatics

• Gene Symbol: C5
• Entrez:
  • 727(Human)