Complement C5 Products

Description

C5 is synthesised in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190kDa glycoprotein consisting of a disulphide linked alpha-chain (115kDa) and beta-chain (75kDa). C5 occurs in plasma at about 75mg/L. It is activated via either the classical or the alternative complement pathway, by protoelytic cleavage of C5a (11.5kDa) from the N-terminal of the alpha-chain. C5a is a potent anaphylotoxin and stimulates directed migration of neutrophils, eosinophils, basophils and monocytes. The other fragment, C5b,initiates the assembly of the membrane attack complex that mediates the cytolysis of viral and bacterial pathogens.

Bioinformatics

Entrez	15139 Mouse 727 Human
Uniprot	NP_001726 Human P01031 Human P06684 Mouse
Product By Gene ID	727
Alternate Names	anaphylatoxin C5a analog C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 C5 complement C5 complement component 5 CPAMD4MGC142298 FLJ17816 FLJ17822

Research Areas for Complement C5

Find related products by research area and learn more about each of the different research areas below.

Immunology
Innate Immunity
Stem Cell Markers

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Complement C3 - The Most Important Protein in the Complement System The complement system is made up of a collection of proteins found in the bloodstream and is comprised of nine major complement proteins; complement C3 is one of them. The complement system is a crucial component of the cellular immune system becau...    Read more.

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