Complement C5 Products

Description

The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.

Bioinformatics

Entrez	727 Human
Uniprot	NP_001726 Human
Product By Gene ID	727
Alternate Names	anaphylatoxin C5a analog C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4 C5 complement C5 complement component 5 CPAMD4MGC142298 FLJ17816 FLJ17822

Research Areas for Complement C5

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Immunology
Innate Immunity

Related Complement C5 Blog Posts

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Complement C3 - The Most Important Protein in the Complement System The complement system is made up of a collection of proteins found in the bloodstream and is comprised of nine major complement proteins; complement C3 is one of them. The complement system is a crucial component of the cellular immune system becau...    Read more.

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