C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
complement component 5
C5 is involved in the activation of the lythic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5. C5a induces smooth muscle contraction, increases vascular permeability, and causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-a, IL-1a, IL-6 and IL-8.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for Complement C5 Antibody (NB110-12179). (Showing 1 - 1 of 1 FAQs).
I am interested in purchasing the following antibody: catalog # NB110-12179 Complement C5 Antibody in which epitope its been raised against? What volume do you get out of 0.05mg? Also, what is its cost?
NB110-12179 is not epitope mapped but it is known that it reacts with an epitope on C5 and C5a. The concentration is 0.1 mg/mL which is a volume of 500 uL. Regarding the price of this product, please use our website to select your country, which will allow you to view the country specific pricing, availability and technical support information.
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