Complement C5 Antibody (557)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, Func, IA, B/N
Clone
557
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.1 mg/ml

Order Details

Complement C5 Antibody (557) Summary

Immunogen
BALB/c mice were immunized with human C5
Specificity
This reacts with an epitope on C5 and C5a.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
C5
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Block/Neutralize
  • ELISA 1:100-1:2000
  • Functional
  • Immunoassay
  • Western Blot 1:1000
Application Notes
IA: Use at an assay dependent dilution. Inhib: Use at an assay dependent dilution. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
Publications
Read Publications using NB110-12179.

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
PBS, 0.1% BSA
Preservative
No Preservative
Concentration
0.1 mg/ml
Purity
Protein G purified

Alternate Names for Complement C5 Antibody (557)

  • anaphylatoxin C5a analog
  • C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
  • C5
  • complement C5
  • complement component 5
  • CPAMD4MGC142298
  • FLJ17816
  • FLJ17822

Background

C5 is involved in the activation of the lythic pathway within the complement system which is an important factor in innate immunity. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5. C5a induces smooth muscle contraction, increases vascular permeability, and causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. Recent studies indicate the modulation of the acute-phase response in liver and an overall immune response by inducing synthesis of cytokines such as TNF-a, IL-1a, IL-6 and IL-8.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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NB110-12179
Species: Hu
Applications: WB, ELISA, Func, IA, B/N

Publications for Complement C5 Antibody (NB110-12179)(3)

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for Complement C5 Antibody (NB110-12179). (Showing 1 - 1 of 1 FAQs).

  1. I am interested in purchasing the following antibody: catalog # NB110-12179 Complement C5 Antibody in which epitope its been raised against? What volume do you get out of 0.05mg? Also, what is its cost?
    • NB110-12179 is not epitope mapped but it is known that it reacts with an epitope on C5 and C5a. The concentration is 0.1 mg/mL which is a volume of 500 uL. Regarding the price of this product, please use our website to select your country, which will allow you to view the country specific pricing, availability and technical support information.

Secondary Antibodies

 

Isotype Controls

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Blogs on Complement C5.

Complement C3 - the most important protein in the complement system
The complement system is made up of a collection of proteins found in the bloodstream and is comprised of nine major complement proteins; complement C3 is one of them. The complement system is a crucial component of the cellular immune system becau...  Read full blog post.

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Bioinformatics

Gene Symbol C5
Entrez
Uniprot