COCO/DAND5 Antibody (OTI2H3)

Images

 
Western Blot: DAND5 Antibody (2H3) [NBP2-01223] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY DAND5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates ...read more
Immunohistochemistry-Paraffin: DAND5 Antibody (2H3) [NBP2-01223] Staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-DAND5 mouse monoclonal antibody.
Flow Cytometry: DAND5 Antibody (2H3) [NBP2-01223] - HEK293T cells transfected with either overexpression plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-DAND5 antibody, and then analyzed ...read more
Immunohistochemistry-Paraffin: DAND5 Antibody (2H3) [NBP2-01223] - Staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-DAND5 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: DAND5 Antibody (2H3) [NBP2-01223] - Staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-DAND5 mouse monoclonal antibody.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, IHC, IHC-P
Clone
OTI2H3
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.04 mg/ml

Order Details

COCO/DAND5 Antibody (OTI2H3) Summary

Immunogen
Human recombinant protein fragment corresponding to amino acids 23-189 of human DAND5(NP_689867) produced in E.coli.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
DAND5
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-2000
  • Flow Cytometry 1:100
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:150
Theoretical MW
18 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Concentration
1.04 mg/ml
Purity
Affinity purified

Alternate Names for COCO/DAND5 Antibody (OTI2H3)

  • CER2CRL2
  • Cerberus 2
  • Cerberus like-2
  • cerberus-like 2
  • Cerberus-like protein 2
  • CERL2
  • cerl-2
  • CKTSF1B3
  • CKTSF1B3MGC126849
  • COCO
  • Cysteine knot superfamily 1, BMP antagonist 3
  • DAN domain family member 5
  • DAN domain family, member 5
  • DAND5
  • Dante
  • DTE
  • FLJ38607
  • GREM3
  • GREM3cerberus 2
  • gremlin-3
  • SP1

Background

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for COCO/DAND5 Antibody (NBP2-01223) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-72456AF350
Alexa Fluor 405 NBP2-72456AF405
Alexa Fluor 488 NBP2-72456AF488
Alexa Fluor 532 NBP2-72456AF532
Alexa Fluor 594 NBP2-72456AF594
Alexa Fluor 647 NBP2-72456AF647
Alexa Fluor 700 NBP2-72456AF700
Alexa Fluor 750 NBP2-72456AF750
Allophycocyanin NBP2-72456APC
Allophycocyanin/Cy7 NBP2-72456APCCY7
Biotin NBP2-72456B
DyLight 350 NBP2-72456UV
DyLight 405 NBP2-72456V
DyLight 488 NBP2-72456G
DyLight 550 NBP2-72456R
DyLight 594 NBP2-72456DL594
DyLight 650 NBP2-72456C
DyLight 680 NBP2-72456FR
DyLight 755 NBP2-72456IR
FITC NBP2-72456F
HRP NBP2-72456H
Janelia Fluor 549 NBP2-72456JF549
Janelia Fluor 646 NBP2-72456JF646
PE NBP2-72456PE
PE/Atto594 NBP2-72456PEATT594
PE/Cy5.5 NBP2-72456PECY55
PE/Cy7 NBP2-72456PECY7
PerCP NBP2-72456PCP

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Bioinformatics Tool for COCO/DAND5 Antibody (NBP2-01223)

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Diseases for COCO/DAND5 Antibody (NBP2-01223)

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Bioinformatics

Gene Symbol DAND5
Entrez