COCO/DAND5 Products

Description

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry.

Bioinformatics

Entrez	199699 Human
Uniprot	NP_689867
Product By Gene ID	199699
Alternate Names	CER2CRL2 Cerberus 2 Cerberus like-2 cerberus-like 2 Cerberus-like protein 2 CERL2 Cerl-2 CKTSF1B3 CKTSF1B3MGC126849 COCO Cysteine knot superfamily 1, BMP antagonist 3 DAN domain family member 5 DAN domain family, member 5 DAND5 Dante DTE FLJ38607 GREM3 GREM3cerberus 2 Gremlin-3 SP1