Coagulation Factor XIV/Protein C Antibody [DyLight 488]

• Reactivity: Mu
• Applications: WB, IP
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: DyLight 488

Coagulation Factor XIV/Protein C Antibody [DyLight 488] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant mouse Coagulation Factor XIV/Protein C
  Ile19-Leu460
  Accession # P33587
• Specificity: Detects mouse Coagulation Factor XIV/Protein C in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant human Protein C is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: PROC
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Coagulation Factor XIV/Protein C Antibody [DyLight 488]

• Anticoagulant protein C
• APC
• Autoprothrombin IIA
• Blood coagulation factor XIV
• Coagulation Factor XIV
• EC 3.4.21
• EC 3.4.21.69
• PC
• PROC
• PROC1
• protein C (inactivator of coagulation factors Va and VIIIa)
• Protein C
• vitamin K-dependent protein C

Background

Protein C is a vitamin K-dependent serine protease that is produced in the liver and made up of 2 polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa inhibiting blood coagulation. The molecular weight of the active enzyme is 55 kDa and the normal concentration in human plasma is approximately 1-3 ng/ml while the concentration of the proenzyme is approximately 3 ug/mL due to the very fast turnover.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PROC